Iron(III)/Iodine-Catalyzed C(sp2)-H Activation of α,β-Unsaturated Aldehydes/Ketones with Amidines: Synthesis of 1,2,4,5-Tetrasubstituted Imidazoles

被引：40

作者：

Wu, Ping ^{[1
,2
]}

Qu, Jinpeng ^{[1
,2
]}

Li, Yaxuan ^{[1
,2
]}

Guo, Xin ^{[1
,2
]}

Tang, Dong ^{[1
,2
]}

Meng, Xu ^{[3
]}

Yan, Rulong ^{[1
,2
]}

Chen, Baohua ^{[1
,2
]}

机构：

[1] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou, Gansu, Peoples R China

[2] Key Lab Nonferrous Met Chem & Resources Utilizat, Lanzhou 730000, Peoples R China

[3] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2015年 / 357卷 / 18期

基金：

中国国家自然科学基金;

关键词：

C-N bond formation; cross-dehydrogenative-coupling (CDC) reaction; highly substituted imidazoles; iron(III) catalysis; alpha; beta-unsaturated aldehydes/ketones; ONE-POT SYNTHESIS; MICROWAVE-ASSISTED SYNTHESIS; CATALYZED DIRECT CYANATION; SP(3) C-H; MULTICOMPONENT SYNTHESIS; SUBSTITUTED IMIDAZOLES; HIGHLY EFFICIENT; MICHAEL REACTION; COPPER; ACID;

D O I：

10.1002/adsc.201500701

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient methodology to access a library of 1,2,4,5-tetrasubstituted imidazoles from a broad range of amidines and alpha,beta-unsaturated aldehydes/ketones via a C(sp(2)) H amination has been developed. This method represents a new and simple way to prepare highly substituted imidazoles from easily available starting materials, inexpensive catalysts, and with good functional group tolerance in good to excellent yields.

引用

页码：3868 / 3874

页数：7

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