A Trial of Pitavastatin Versus Rosuvastatin for Dyslipidemia in Chronic Kidney Disease

被引:8
作者
Abe, Masanori [1 ]
Maruyama, Noriaki [1 ]
Maruyama, Takashi [1 ]
Okada, Kazuyoshi [1 ]
Soma, Masayoshi [1 ]
机构
[1] Nihon Univ, Sch Med, Div Nephrol Hypertens & Endocrinol, Dept Internal Med, Tokyo 1738610, Japan
关键词
Statins; Cardiovascular disease; Chronic kidney disease; Lipid lowering effectiveness; Cost effectiveness; GLOMERULAR-FILTRATION-RATE; LIPID-LOWERING THERAPY; OXIDATIVE STRESS; RENAL-FUNCTION; CARDIOVASCULAR EVENTS; PRAVASTATIN; CORONARY; SAFETY; RISK; ATORVASTATIN;
D O I
10.5551/jat.29264
中图分类号
R6 [外科学];
学科分类号
1002 ; 100210 ;
摘要
Aim: To determine the lipid lowering effectiveness, cost effectiveness, and safety of rosuvastatin compared with pitavastatin in dyslipidemic patients with concurrent renal disorders. Methods: This single-center, prospective, open-label, randomized, 12-month study evaluated rosuvastatin (2.5 mg) and pitavastatin (1 or 2 mg) in 134 dyslipidemic patients with concurrent chronic kidney disease (CKD; rosuvastatin group, n = 68; pitavastatin group, n = 66). Lipid parameters [i.e., low density lipoprotein cholesterol (LDL-C), etc.], renal function parameters [i.e., estimated glomerular filtration rate (eGFR), etc.], glycated hemoglobin (HbA1c), and high-sensitivity C-reactive protein (hs-CRP) were measured at enrollment (baseline), month 6, and month 12. Results: The mean daily dose of rosuvastatin and pitavastatin was 2.5 mg and 1.4 mg, respectively. All lipid parameters were significantly more improved in the rosuvastatin group. eGFR improved from baseline in the rosuvastatin group (p<0.0001) and showed no tendency to worsen in the pitavastatin group (p = 0.2232). In multiple regression analysis (n = 134), it was significantly associated with a percent change in total cholesterol (beta = 0.2296; p = 0.0112), smoking (beta = 0.1927; p = 0.0224), and HbA1c (beta = -0.1606; p = 0.0585). Hs-CRP was significantly improved in both groups. An analysis eliminating the influence of antidiabetic medication showed a significant difference between groups in the change of HbA1c at month 6 from baseline (p = 0.0016). No subjects in either group had new onset of diabetes mellitus. The cost of statin medication required to reduce LDL-C by 10 mg/dL was significantly lower for 2.5 mg of rosuvastatin (p = 0.0116). Conclusions: Rosuvastatin 2.5 mg had superior lipid lowering and cost effectiveness in dyslipidemic patients with concurrent CKD.
引用
收藏
页码:1235 / 1247
页数:13
相关论文
共 31 条
[1]  
Abe M, 2011, J ATHEROSCLER THROMB, V18, P1018
[2]   Efficacy analysis of the lipid-lowering and renoprotective effects of rosuvastatin in patients with chronic kidney disease [J].
Abe, Masanori ;
Maruyama, Noriaki ;
Yoshida, Yoshinori ;
Ito, Midori ;
Okada, Kazuyoshi ;
Soma, Masayoshi .
ENDOCRINE JOURNAL, 2011, 58 (08) :663-674
[3]   Association of albuminuria and reduced estimated glomerular filtration rate with incident stroke and coronary artery disease in patients with type 2 diabetes [J].
Bouchi, Ryotaro ;
Babazono, Tetsuya ;
Yoshida, Naoshi ;
Nyumura, Izumi ;
Toya, Kiwako ;
Hayashi, Toshihide ;
Hanai, Ko ;
Tanaka, Nobue ;
Ishii, Akiko ;
Iwamoto, Yasuhiko .
HYPERTENSION RESEARCH, 2010, 33 (12) :1298-1304
[4]   Risk of incident diabetes among patients treated with statins: population based study [J].
Carter, Aleesa A. ;
Gomes, Tara ;
Camacho, Ximena ;
Juurlink, David N. ;
Shah, Baiju R. ;
Mamdani, Muhammad M. .
BMJ-BRITISH MEDICAL JOURNAL, 2013, 346
[5]   Effects of Atorvastatin on Kidney Outcomes and Cardiovascular Disease in Patients With Diabetes: An Analysis From the Collaborative Atorvastatin Diabetes Study (CARDS) [J].
Colhoun, Helen M. ;
Betteridge, D. John ;
Durrington, Paul N. ;
Hitman, Graham A. ;
Neil, H. Andrew W. ;
Livingstone, Shona J. ;
Charlton-Menys, Valentine ;
DeMicco, David A. ;
Fuller, John H. .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2009, 54 (05) :810-819
[6]  
Collins R, 2002, LANCET, V360, P7, DOI 10.1016/S0140-6736(02)09327-3
[7]   Rosuvastatin protects against podocyte apoptosis in vitro [J].
Cormack-Aboud, Fionnuala C. ;
Brinkkoetter, Paul T. ;
Pippin, Jeffrey W. ;
Shankland, Stuart J. ;
Durvasula, Raghu V. .
NEPHROLOGY DIALYSIS TRANSPLANTATION, 2009, 24 (02) :404-412
[8]   K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification - Foreword [J].
Eknoyan, G ;
Levin, NW .
AMERICAN JOURNAL OF KIDNEY DISEASES, 2002, 39 (02) :S14-S266
[9]   Effect of lipid reduction on the progression of renal disease: A meta-analysis [J].
Fried, LF ;
Orchard, TJ ;
Kasiske, BL .
KIDNEY INTERNATIONAL, 2001, 59 (01) :260-269
[10]   Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats [J].
Girardi, Jose Marcos ;
Farias, Rogerio Estevan ;
Ferreira, Ana Paula ;
Barbosa Raposo, Nadia Rezende .
CLINICS, 2011, 66 (08) :1457-1462