CRF ligands via Suzuki and Negishi couplings of 3-pyridyl boronic acids or halides with 2-benzyloxy-4-chloro-3-nitropyridine

被引：6

作者：

Arvanitis, AG ^{[1
]}

Arnold, CR

Fitzgerald, LW

Frietze, WE

Olson, RE

Gilligan, PJ

Robertson, DW

机构：

[1] Bristol Myers Squibb Co, Discovery Chem Wilmington, Expt Stn, Wilmington, DE 19880 USA

[2] Bristol Myers Squibb Co, CNS Dis Res, Expt Stn, Wilmington, DE 19880 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(02)00835-1

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of imidazo[4,5-b]pyridines with a 7-(3-pyridyl) substituent is described as high affinity CRF receptor ligands. Individual analogues were synthesized from key intermediates obtained via palladium-catalyzed coupling of 3-pyridyl zinc or boronic acid organometallic intermediates with 2-benzyloxy-4-chloro-3-nitropyridine 12. (C) 2002 Elsevier Science Ltd. All rights reserved.

引用

页码：289 / 291

页数：3

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