Primary brain tumours in adults

被引：669

作者：

Behin, A ^{[1
]}

Hoang-Xuan, K ^{[1
]}

Carpentier, AF ^{[1
]}

Delattre, JY ^{[1
]}

机构：

[1] GH Pitie Salpetriere, Federat Neurol Mazarin, F-75013 Paris, France

来源：

LANCET | 2003年 / 361卷 / 9354期

关键词：

D O I：

10.1016/S0140-6736(03)12328-8

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The most frequent primary brain tumours in adults are gliomas and primary CNS lymphomas. In gliomas, molecular genetic analysis plays an increasing part in classification and treatment planning, a feature well illustrated by the chemosensitive oligodendrogliomas. Unfortunately, management of glioblastoma is still mainly palliative. Incidence of primary CNS lymphoma has increased strikingly in the past 20 years; substantial progress has been achieved in patients who are immunocompetent with the addition of methotrexate-based chemotherapy to radiotherapy, but the potential neurotoxic effects of this combination in elderly patients is worrisome.

引用

页码：323 / 331

页数：9

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