Ondamtanggamibang protects neurons from oxidative stress with induction of heme oxygenase-1

被引：12
作者：
Lee, Myeong Soo
Lee, Jienny
Kwon, Dae Young
Kim, Myung-Sunny
机构：
[1] Korea Food Res Inst, Songnam 463746, Kyongki Do, South Korea
[2] Wonkwang Univ, Inst Med Sci, Ctr Integrat Med, Iksan 570749, South Korea
[3] Wonkwang Univ, Profess Grad Sch Oriental Med, Iksan 570749, South Korea
来源：
JOURNAL OF ETHNOPHARMACOLOGY | 2006年 / 108卷 / 02期
关键词：
ondamtanggamibang; oxidative stress; heme oxygenase-1; zinc protoporphyrin IX; TRADITIONAL HERBAL REMEDY; PLACEBO-CONTROLLED TRIAL; NERVE GROWTH-FACTOR; HYDROGEN-PEROXIDE; CYPERUS-ROTUNDUS; H2O2-INDUCED APOPTOSIS; NITRIC-OXIDE; PC12; CELLS; INJURY; ACTIVATION;
D O I：
10.1016/j.jep.2006.05.012
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
Ondamtanggamibang (ODG) has been used as a remedy to treat psychological anxiety and depression in Oriental medicine. In this study, we found the protective effects of ODG against oxidative stress by induction of the antioxidative enzyme, heme oxygenase (HO)-1 in neuronal PC 12 cells. Pretreatment with ODG extract protected neuronal cells from damage induced by H2O2 and 6-hydroxydopamine (6-OHDA), but simultaneous treatment with ODG extract did not. ODG also inhibited the intracellular reactive oxygen species elevation by H2O2 and 6-OHDA. ODG stimulation strongly induced the expression of HO-I in PC12 cells. The protective effect of ODG extract on oxidative stress-induced damage was suppressed by HO inhibitor, zinc protoporphyrin IX (ZnPP-IX). Taken together, these data suggest that ODG treatment has potential protective effects in neuronal cells under oxidative stress. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：294 / 298
页数：5
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