An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections

被引：14

作者：

Leon, Kristoffer ^{[1
,2
]}

Ott, Melanie ^{[1
,2
]}

机构：

[1] J David Gladstone Inst, San Francisco, CA USA

[2] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2021年 / 111卷

关键词：

Viruses; RNA biology; Nonsense-mediated mRNA decay; Anti-viral response; CAULIFLOWER-MOSAIC-VIRUS; EXON-JUNCTION COMPLEX; PLANT-PATHOGEN; RECRUITS UPF1; GAG GENE; SURVEILLANCE; STABILITY; PROTEIN; CODONS; PHOSPHORYLATION;

D O I：

10.1016/j.semcdb.2020.05.018

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.

引用

页码：101 / 107

页数：7

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