Organocatalysis of asymmetric aldol reaction. Catalysts and reagents

被引：110
作者：
Zlotin, S. G. [1 ]
Kucherenko, A. S. [1 ]
Beletskaya, I. P. [2 ]
机构：
[1] Russian Acad Sci, ND Zelinsky Inst Organ Chem, Moscow 119991, Russia
[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119991, Russia
来源：
RUSSIAN CHEMICAL REVIEWS | 2009年 / 78卷 / 08期
基金：
俄罗斯基础研究基金会;
关键词：
DE-NOVO SYNTHESIS; CHIRAL AMINO-ACID; HIGHLY EFFICIENT ORGANOCATALYSTS; LIQUID-SUPPORTED ORGANOCATALYST; SILOXY SERINE ORGANOCATALYST; DENSITY-FUNCTIONAL THEORY; SAUER-WIECHERT REACTION; SMALL ORGANIC-MOLECULE; L-PROLINE AMIDE; ENANTIOSELECTIVE ALDOL;
D O I：
10.1070/RC2009v078n08ABEH004040
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The review is devoted to the application of organocatalysis for the asymmetric aldol reaction, which is one of the most important methods for carbon-carbon bond formation in organic compounds. The mechanism of enamine catalysis and the main types of organocatalysts for the aldol reaction are considered, data on this type of reactions involving carbonyl compounds with various electronic and spatial structures are classified. The effects of organocatalyst structure on the regio-, stereo- and enantio-selectivity of intramolecular and intermolecular aldol react ions are reviewed. The bibliography includes 355 references.
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收藏
页码：737 / 784
页数：48
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