Safety and efficacy of the BRAF inhibitor dabrafenib in relapsed or refractory hairy cell leukemia: a pilot phase-2 clinical trial

被引：34
作者：
Tiacci, Enrico [1 ]
De Carolis, Luca [1 ]
Simonetti, Edoardo [1 ]
Merluzzi, Mara [1 ]
Bennati, Antonio [1 ]
Perriello, Vincenzo Maria [1 ]
Pucciarini, Alessandra [1 ]
Santi, Alessia [1 ]
Venanzi, Alessandra [1 ]
Pettirossi, Valentina [1 ]
Schiavoni, Gianluca [1 ]
Tasselli, Luisa [1 ]
Ascani, Stefano [2 ,3 ]
Volpetti, Stefano [4 ]
Falini, Brunangelo [1 ]
机构：
[1] Univ & Hosp Perugia, Hematol, Perugia, Italy
[2] Univ Perugia, Anat Pathol, Perugia, Italy
[3] Hosp Terni, Perugia, Italy
[4] Azienda Sanitaria Univ Integrata, Clin Ematol, Udine, Italy
来源：
LEUKEMIA | 2021年 / 35卷 / 11期
基金：
欧洲研究理事会;
关键词：
MELANOMA; VEMURAFENIB; DIAGNOSIS; THERAPY;
D O I：
10.1038/s41375-021-01210-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
[No abstract available]
引用
收藏
页码：3314 / 3318
页数：5
相关论文
共 18 条
  • [1] Cotreatment of Hairy Cell Leukemia and Melanoma With the BRAF Inhibitor Dabrafenib
    Blachly, James S.
    Lozanski, Gerard
    Lucas, David M.
    Grever, Michael R.
    Kendra, Kari
    Andritsos, Leslie A.
    [J]. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK, 2015, 13 (01): : 9 - 13
  • [2] Secondary Tumors Arising in Patients Undergoing BRAF Inhibitor Therapy Exhibit Increased BRAF-CRAF Heterodimerization
    Boussemart, Lise
    Girault, Isabelle
    Malka-Mahieu, Helene
    Mateus, Christine
    Routier, Emilie
    Rubington, Margot
    Kamsu-Kom, Nyam
    Thomas, Marina
    Tomasic, Gorana
    Agoussi, Sandrine
    Breckler, Marie
    Laporte, Melanie
    Lacroix, Ludovic
    Eggermont, Alexander M.
    Cavalcanti, Andrea
    Grange, Florent
    Adam, Julien
    Vagner, Stephan
    Robert, Caroline
    [J]. CANCER RESEARCH, 2016, 76 (06) : 1476 - 1484
  • [3] Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation
    Chapman, Paul B.
    Hauschild, Axel
    Robert, Caroline
    Haanen, John B.
    Ascierto, Paolo
    Larkin, James
    Dummer, Reinhard
    Garbe, Claus
    Testori, Alessandro
    Maio, Michele
    Hogg, David
    Lorigan, Paul
    Lebbe, Celeste
    Jouary, Thomas
    Schadendorf, Dirk
    Ribas, Antoni
    O'Day, Steven J.
    Sosman, Jeffrey A.
    Kirkwood, John M.
    Eggermont, Alexander M. M.
    Dreno, Brigitte
    Nolop, Keith
    Li, Jiang
    Nelson, Betty
    Hou, Jeannie
    Lee, Richard J.
    Flaherty, Keith T.
    McArthur, Grant A.
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2011, 364 (26) : 2507 - 2516
  • [4] Long-term follow-up after purine analogue therapy in hairy cell leukaemia
    Else, Monica
    Dearden, Claire E.
    Catovsky, Daniel
    [J]. BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2015, 28 (04) : 217 - 229
  • [5] New treatment options in hairy cell leukemia with focus on BRAF inhibitors
    Falini, Brunangelo
    Tiacci, Enrico
    [J]. HEMATOLOGICAL ONCOLOGY, 2019, 37 : 30 - 37
  • [6] BRAF V600E mutation in hairy cell leukemia: from bench to bedside
    Falini, Brunangelo
    Martelli, Maria Paola
    Tiacci, Enrico
    [J]. BLOOD, 2016, 128 (15) : 1918 - 1927
  • [7] Consensus guidelines for the diagnosis and management of patients with classic hairy cell leukemia
    Grever, Michael R.
    Abdel-Wahab, Omar
    Andritsos, Leslie A.
    Banerji, Versha
    Barrientos, Jacqueline
    Blachly, James S.
    Call, Timothy G.
    Catovsky, Daniel
    Dearden, Claire
    Demeter, Judit
    Else, Monica
    Forconi, Francesco
    Gozzetti, Alessandro
    Ho, Anthony D.
    Johnston, James B.
    Jones, Jeffrey
    Juliusson, Gunnar
    Kraut, Eric
    Kreitman, Robert J.
    Larratt, Loree
    Lauria, Francesco
    Lozanski, Gerard
    Montserrat, Emili
    Parikh, Sameer A.
    Park, Jae H.
    Polliack, Aaron
    Quest, Graeme R.
    Rai, Kanti R.
    Ravandi, Farhad
    Robak, Tadeusz
    Saven, Alan
    Seymour, John F.
    Tadmor, Tamar
    Tallman, Martin S.
    Tam, Constantine
    Tiacci, Enrico
    Troussard, Xavier
    Zent, Clive S.
    Zenz, Thorsten
    Zinzani, Pier Luigi
    Falini, Brunangelo
    [J]. BLOOD, 2017, 129 (05) : 553 - 560
  • [8] Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    Hauschild, Axel
    Grob, Jean-Jacques
    Demidov, Lev V.
    Jouary, Thomas
    Gutzmer, Ralf
    Millward, Michael
    Rutkowski, Piotr
    Blank, Christian U.
    Miller, Wilson H., Jr.
    Kaempgen, Eckhart
    Martin-Algarra, Salvador
    Karaszewska, Boguslawa
    Mauch, Cornelia
    Chiarion-Sileni, Vanna
    Martin, Anne-Marie
    Swann, Suzanne
    Haney, Patricia
    Mirakhur, Beloo
    Guckert, Mary E.
    Goodman, Vicki
    Chapman, Paul B.
    [J]. LANCET, 2012, 380 (9839) : 358 - 365
  • [9] Successful switch to dabrafenib after vemurafenib-induced toxic epidermal necrolysis
    Jeudy, G.
    Dalac-Rat, S.
    Bonniaud, B.
    Hervieu, A.
    Petrella, T.
    Collet, E.
    Vabres, P.
    [J]. BRITISH JOURNAL OF DERMATOLOGY, 2015, 172 (05) : 1454 - 1455
  • [10] Moxetumomab pasudotox in relapsed/refractory hairy cell leukemia
    Kreitman, Robert J.
    Dearden, Claire
    Zinzani, Pier Luigi
    Delgado, Julio
    Karlin, Lionel
    Robak, Tadeusz
    Gladstone, Douglas E.
    le Coutre, Philipp
    Dietrich, Sascha
    Gotic, Mirjana
    Larratt, Loree
    Offner, Fritz
    Schiller, Gary
    Swords, Ronan
    Bacon, Larry
    Bocchia, Monica
    Bouabdallah, Krimo
    Breems, Dimitri A.
    Cortelezzi, Agostino
    Dinner, Shira
    Doubek, Michael
    Gjertsen, Bjorn Tore
    Gobbi, Marco
    Hellmann, Andrzej
    Lepretre, Stephane
    Maloisel, Frederic
    Ravandi, Farhad
    Rousselot, Philippe
    Rummel, Mathias
    Siddiqi, Tanya
    Tadmor, Tamar
    Troussard, Xavier
    Yi, Cecilia Arana
    Saglio, Giuseppe
    Roboz, Gail J.
    Balic, Kemal
    Standifer, Nathan
    He, Peng
    Marshall, Shannon
    Wilson, Wyndham
    Pastan, Ira
    Yao, Nai-Shun
    Giles, Francis
    [J]. LEUKEMIA, 2018, 32 (08) : 1768 - 1777
12