Trimethylsilylpyrazoles as novel inhibitors of p38 MAP kinase: A new use of silicon bioisosteres in medicinal chemistry

被引：61

作者：

Barnes, Matthew J. ^{[1
]}

Conroy, Richard ^{[1
]}

Miller, David J. ^{[1
]}

Mills, John S. ^{[1
]}

Montana, John G. ^{[1
]}

Pooni, Parminder K. ^{[1
]}

Showell, Graham A. ^{[1
]}

Walsh, Louise M. ^{[1
]}

Warneck, Julie B. H. ^{[1
]}

机构：

[1] Paradigm Therapeut Ltd, Cambridge CB4 0PA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期

关键词：

silicon bioisostere; p38 MAP kinase;

D O I：

10.1016/j.bmcl.2006.10.044

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：354 / 357

页数：4

共 14 条

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