Novel poly(ADP-ribose) polymerase-1 inhibitors

被引：17
|
作者：
Dunn, Derek [1 ]
Husten, Jean [1 ]
Ator, Mark A. [1 ]
Chatterjee, Sankar [1 ]
机构：
[1] Cephalon Inc, W Chester, PA 19380 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2007年 / 17卷 / 02期
关键词：
PARP-1; pyrrolocarbazole; thiazole;
D O I：
10.1016/j.bmcl.2006.10.010
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Synthesis and activity of a series of 4-thiazol-yl substituted analogs of novel pyrrolocarbazole 1 as poly(ADP-ribose) polymerase-1 (PARP-1) inhibitors have been disclosed. (c) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码：542 / 545
页数：4
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