Antifungal activity of β-lapachone against Candida spp. resistant to azoles and its aspects upon biofilm formation

被引：3
作者：
da Silva, Cecilia R. [1 ,2 ]
Campos, Rosana de S. [1 ,6 ]
Neto, Joao B. de A. [1 ,6 ]
Sampaio, Leticia S. [1 ,2 ]
do Nascimento, Francisca B. S. A. [1 ,2 ]
do AV Sa, Livia G. [1 ,2 ]
Candido, Thiago M. [1 ,2 ]
Magalhaes, Hemerson I. F. [3 ]
da Cruz, Eduardo H. G. [4 ]
Junior, Eufranio N. da S. [4 ]
de Moraes, Manoel O. [5 ]
Cavalcanti, Bruno C. [5 ]
Silva, Jacilene [7 ]
Marinho, Emmanuel S. [7 ]
Junior, Helio V. N. [1 ,2 ]
机构：
[1] Univ Fed Ceara, Drug Res & Dev Ctr, Lab Bioprospect Antimicrobial Mol LABIMAN, BR-60430275 Fortaleza, CE, Brazil
[2] Univ Fed Ceara, Sch Pharm, Dept Clin & Toxicol Anal, Lab Bioprospect Antimicrobial Mol LABIMAN, BR-60430170 Fortaleza, CE, Brazil
[3] Univ Fed Paraiba, Sch Pharm, BR-58059900 Joao Pessoa, PB, Brazil
[4] Univ Fed Minas Gerais, Inst Exact Sci, Dept Chem, Lab Synthet & Heterocycl Chem, BR-31270901 Belo Horizonte, MG, Brazil
[5] Univ Fed Ceara, Drug Res & Dev Ctr, BR-60430275 Fortaleza, CE, Brazil
[6] Christus Univ Ctr UNICHRISTUS, BR-60160230 Fortaleza, CE, Brazil
[7] StateUniv Ceara, Grp Theoret Chem & Electrochem GQTE, Dept Chem, BR-62930000 Limoeiro Do Norte, Ceara, Brazil
来源：
FUTURE MICROBIOLOGY | 2020年 / 15卷 / 16期
关键词：
biofilms; Candida spp; flow cytometry; mechanism of action; resistance; β -lapachone; STAPHYLOCOCCUS-AUREUS; ANTIMICROBIAL ACTIVITY; ALBICANS; FLUCONAZOLE; NAPHTHOQUINONE; APOPTOSIS; EMPHASIS; EPIDEMIOLOGY; STRATEGIES; SYNERGY;
D O I：
10.2217/fmb-2020-0011
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
Aim: The purpose of this study was to assess the antifungal effect of beta-lapachone (beta-lap) on azole-resistant strains of Candida spp. in both planktonic and biofilm form. Materials & methods: The antifungal activity of beta-lap was evaluated by broth microdilution, flow cytometry and the comet assay. The cell viability of the biofilms was assessed using the MTT assay. Results: beta-lap showed antifungal activity against resistant strains of Candida spp. in planktonic form. In addition, beta-lap decreased the viability of mature biofilms and inhibited the formation of biofilms in vitro. Conclusion: beta-lap showed antifungal activity against Candida spp., suggesting that the compound can be utilized as an adjunct agent in the treatment of candidiasis.
引用
收藏
页码：1543 / 1554
页数：12
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