Bone marrow CD34+progenitor cells may harbour HIV-DNA even in successfully treated patients

被引：11

作者：

Bordoni, V. ^{[1
]}

Bibas, M. ^{[2
]}

Abbate, I.

Viola, D. ^{[1
]}

Rozera, G. ^{[3
]}

Agrati, C. ^{[1
,3
]}

Rinaldi, A. ^{[1
]}

Amendola, A. ^{[3
]}

Ammassari, A. ^{[2
]}

Capobianchi, M. R. ^{[3
]}

Martini, F. ^{[1
]}

机构：

[1] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Cellular Immunol Lab, I-00149 Rome, Italy

[2] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Clin Dept, I-00149 Rome, Italy

[3] IRCCS, Natl Inst Infect Dis Lazzaro Spallanzani, Virol Lab, I-00149 Rome, Italy

来源：

CLINICAL MICROBIOLOGY AND INFECTION | 2015年 / 21卷 / 03期

关键词：

Bone marrow; hematopoietic progenitor cells; HIV infection; proviral DNA; viral load; HEMATOPOIETIC PROGENITOR CELLS; HUMAN-IMMUNODEFICIENCY-VIRUS; ANTIRETROVIRAL THERAPY; MAJOR RESERVOIR; INFECTION;

D O I：

10.1016/j.cmi.2014.11.003

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

The issue about bone marrow hematopoietic progenitor cells harbouring HIV-DNA in infected patients is still under scrutiny. We studied nine HIV-infected individuals undergoing bone marrow aspiration for diagnostic purposes. In all patients, even in those receiving successful antiretroviral therapy for several years, HIV-DNA was detected in purified CD34+ lineage-bone marrow progenitor cells. This finding, although not conclusive due to the low number of patients examined, adds further evidence that current treatment strategies may be insufficient to resolve latent infection in bone marrow CD34+ hematopoietic progenitor cells. Clinical Microbiology and Infection (C) 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.

引用

页码：290.e5 / 290.e8

页数：4

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