Applications of Functionalized Carbon Nanotubes for the Therapy and Diagnosis of Cancer

被引:51
作者
Hwang, Yongsung [1 ,2 ]
Park, Sung-Hoon [3 ]
Lee, Jin Woo [4 ]
机构
[1] Soonchunhyang Univ, Soonchunhyang Inst Medibio Sci, Cheonan Si 31151, Chungcheongnam, South Korea
[2] Soonchunhyang Univ, Inst Tissue Regenerat, Coll Med, Cheonan Si 31151, Chungcheongnam, South Korea
[3] Soongsil Univ, Dept Mech Engn, Seoul 06978, South Korea
[4] Gachon Univ, Dept Mol Med, Sch Med, Incheon 21999, South Korea
基金
新加坡国家研究基金会;
关键词
carbon nanotubes (CNTs); cancer; therapy; nano-carriers; functionalization; NEAR-INFRARED WINDOW; IN-VIVO; PLASMID DNA; INTRACELLULAR DELIVERY; GENE-THERAPY; PHOTOACOUSTIC TOMOGRAPHY; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; RAMAN-SCATTERING; CONTRAST AGENT;
D O I
10.3390/polym9010013
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Carbon nanotubes (CNTs) are attractive nanostructures that serve as multifunctional transporters in biomedical applications, especially in the field of cancer therapy and diagnosis. Owing to their easily tunable nature and remarkable properties, numerous functionalizations and treatments of CNTs have been attempted for their utilization as hybrid nano-carriers in the delivery of various anticancer drugs, genes, proteins, and immunotherapeutic molecules. In this review, we discuss the current advances in the applications of CNT-based novel delivery systems with an emphasis on the various functionalizations of CNTs. We also highlight recent findings that demonstrate their important roles in cancer imaging applications, demonstrating their potential as unique agents with high-level ultrasonic emission, strong Raman scattering resonance, and magnetic properties.
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页数:26
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