Applications of Functionalized Carbon Nanotubes for the Therapy and Diagnosis of Cancer

被引:51
作者
Hwang, Yongsung [1 ,2 ]
Park, Sung-Hoon [3 ]
Lee, Jin Woo [4 ]
机构
[1] Soonchunhyang Univ, Soonchunhyang Inst Medibio Sci, Cheonan Si 31151, Chungcheongnam, South Korea
[2] Soonchunhyang Univ, Inst Tissue Regenerat, Coll Med, Cheonan Si 31151, Chungcheongnam, South Korea
[3] Soongsil Univ, Dept Mech Engn, Seoul 06978, South Korea
[4] Gachon Univ, Dept Mol Med, Sch Med, Incheon 21999, South Korea
基金
新加坡国家研究基金会;
关键词
carbon nanotubes (CNTs); cancer; therapy; nano-carriers; functionalization; NEAR-INFRARED WINDOW; IN-VIVO; PLASMID DNA; INTRACELLULAR DELIVERY; GENE-THERAPY; PHOTOACOUSTIC TOMOGRAPHY; ANTITUMOR-ACTIVITY; TARGETED DELIVERY; RAMAN-SCATTERING; CONTRAST AGENT;
D O I
10.3390/polym9010013
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
Carbon nanotubes (CNTs) are attractive nanostructures that serve as multifunctional transporters in biomedical applications, especially in the field of cancer therapy and diagnosis. Owing to their easily tunable nature and remarkable properties, numerous functionalizations and treatments of CNTs have been attempted for their utilization as hybrid nano-carriers in the delivery of various anticancer drugs, genes, proteins, and immunotherapeutic molecules. In this review, we discuss the current advances in the applications of CNT-based novel delivery systems with an emphasis on the various functionalizations of CNTs. We also highlight recent findings that demonstrate their important roles in cancer imaging applications, demonstrating their potential as unique agents with high-level ultrasonic emission, strong Raman scattering resonance, and magnetic properties.
引用
收藏
页数:26
相关论文
共 136 条
  • [1] Targeted gold nanorod contrast agent for prostate cancer detection by photoacoustic imaging
    Agarwal, A.
    Huang, S. W.
    O'Donnell, M.
    Day, K. C.
    Day, M.
    Kotov, N.
    Ashkenazi, S.
    [J]. JOURNAL OF APPLIED PHYSICS, 2007, 102 (06)
  • [2] In vivo biodistribution and biological impact of injected carbon nanotubes using magnetic resonance techniques
    Al Faraj, Achraf
    Fauvelle, Florence
    Luciani, Nathalie
    Lacroix, Ghislaine
    Levy, Michael
    Cremillieux, Yannick
    Canet-Soulas, Emmanuelle
    [J]. INTERNATIONAL JOURNAL OF NANOMEDICINE, 2011, 6 : 351 - 361
  • [3] In Vivo Imaging of Carbon Nanotube Biodistribution Using Magnetic Resonance Imaging
    Al Faraj, Achraf
    Cieslar, Katarzyna
    Lacroix, Ghislaine
    Gaillard, Sophie
    Canot-Soulas, Emmanuelle
    Cremillieux, Yannick
    [J]. NANO LETTERS, 2009, 9 (03) : 1023 - 1027
  • [4] Multiwalled carbon nanotube-doxorubicin supramolecular complexes for cancer therapeutics
    Ali-Boucetta, Hanene
    Al-Jamal, Khuloud T.
    McCarthy, David
    Prato, Maurizio
    Bianco, Alberto
    Kostarelos, Kostas
    [J]. CHEMICAL COMMUNICATIONS, 2008, (04) : 459 - 461
  • [5] Ultra-Low Doses of Chirality Sorted (6,5) Carbon Nanotubes for Simultaneous Tumor Imaging and Photothermal Therapy
    Antaris, Alexander L.
    Robinson, Joshua T.
    Yaghi, Omar K.
    Hong, Guosong
    Diao, Shuo
    Luong, Richard
    Dai, Hongjie
    [J]. ACS NANO, 2013, 7 (04) : 3644 - 3652
  • [6] The Way to Nanoarchitectonics and the Way of Nanoarchitectonics
    Aono, Masakazu
    Ariga, Katsuhiko
    [J]. ADVANCED MATERIALS, 2016, 28 (06) : 989 - 992
  • [7] What are the emerging concepts and challenges in NANO? Nanoarchitectonics, hand-operating nanotechnology and mechanobiology
    Ariga, Katsuhiko
    Minami, Kosuke
    Ebara, Mitsuhiro
    Nakanishi, Jun
    [J]. POLYMER JOURNAL, 2016, 48 (04) : 371 - 389
  • [8] Nanoarchitectonics: a new materials horizon for nanotechnology
    Ariga, Katsuhiko
    Ji, Qingmin
    Nakanishi, Waka
    Hill, Jonathan P.
    Aono, Masakazu
    [J]. MATERIALS HORIZONS, 2015, 2 (04) : 406 - 413
  • [9] Bioinspired nanoarchitectonics as emerging drug delivery systems
    Ariga, Katsuhiko
    Kawakami, Kohsaku
    Ebara, Mitsuhiro
    Kotsuchibashi, Yohei
    Ji, Qingmin
    Hill, Jonathan P.
    [J]. NEW JOURNAL OF CHEMISTRY, 2014, 38 (11) : 5149 - 5163
  • [10] Near-infrared optical sensors based on single-walled carbon nanotubes
    Barone, PW
    Baik, S
    Heller, DA
    Strano, MS
    [J]. NATURE MATERIALS, 2005, 4 (01) : 86 - U16