Cobalt-Catalyzed Ortho-C(sp2)-H Amidation of Benzaldehydes with Dioxazolones Using Transient Directing Groups

被引：46

作者：

Huang, Jie ^{[1
]}

Ding, Jun ^{[2
,3
]}

Ding, Tong-Mei ^{[2
,3
]}

Zhang, Shuiyi ^{[1
]}

Wang, Yaqiu ^{[1
]}

Sha, Feng ^{[1
]}

Zhang, Shu-Yu ^{[2
,3
]}

Wu, Xin-Yan ^{[1
]}

Li, Qiong ^{[1
]}

机构：

[1] East China Univ Sci & Technol, Sch Chem & Mol Engn, Shanghai 200237, Peoples R China

[2] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Shanghai 200240, Peoples R China

[3] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 18期

基金：

上海市自然科学基金;

关键词：

C-H AMIDATION; SELECTIVE AMIDATION; BOND AMIDATION; AMINATION; ALDEHYDES; FUNCTIONALIZATION; ARENES; 2-AMINOBENZALDEHYDES; DERIVATIVES; ALKYLAMINES;

D O I：

10.1021/acs.orglett.9b02632

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and convenient cobalt-catalyzed ortho-C(sp(2))-H amidation of benzaldehydes employing dioxazolones as the aminating reagent has been developed. The key feature of this protocol is the use of green and economic earth-abundant metals cobalt as the catalyst with the p-chloroaniline as the transient directing group. Further application of our approach was demonstrated by the synthesis of C1r serine protease inhibitor 45 and elastase inhibitor 49.

引用

页码：7342 / 7345

页数：4

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