Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats

被引：8

作者：

Katayama, Nao ^{[1
]}

Oti, Takumi ^{[1
]}

Takanami, Keiko ^{[1
]}

Sakamoto, Tatsuya ^{[1
]}

Sakamoto, Hirotaka ^{[1
]}

机构：

[1] Okayama Univ, Grad Sch Nat Sci & Technol, UMI, 130-17 Kashino, Setouchi, Okayama 7014303, Japan

来源：

PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES | 2016年 / 92卷 / 02期

关键词：

androgens; gastrin-releasing peptide; sexual differentiation; male sexual behavior; spinal cord; puberty; DEVELOPING NEUROMUSCULAR SYSTEM; VERTEBRATE NERVOUS-SYSTEM; FEMALE RATS; HORMONAL-CONTROL; ITCH SENSATION; ACTIVATION; BEHAVIOR; RECEPTOR; NUCLEUS; NEURONS;

D O I：

10.2183/pjab.92.69

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A sexually dimorphic spinal gastrin-releasing peptide (GRP) system in the lumbosacral spinal cord, which projects to the lower spinal centers, controls erection and ejaculation in rats. However, little is known about the postnatal development of this system. In this study, we therefore examined the postnatal development of the male-dominant spinal GRP system and its sexual differentiation in rats using immunohistochemistry. Our results show that male-dominant expression of GRP is prominent from the onset of puberty and that sexually dimorphism persists into adulthood. These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord.

引用

页码：69 / 75

页数：7

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