Design of spectral-spatial outer volume suppression RF pulses for tissue specific metabolic characterization with hyperpolarized 13C pyruvate

被引：24

作者：

Chen, Albert P. ^{[1
]}

Leung, Kevin ^{[2
]}

Lam, Wilfred ^{[2
]}

Hurd, Ralph E. ^{[3
]}

Vigneron, Daniel B. ^{[4
]}

Cunningham, Charles H. ^{[2
]}

机构：

[1] GE Healthcare, Toronto, ON M5V 3Y3, Canada

[2] Sunnybrook Hlth Sci Ctr, Toronto, ON M4N 3M5, Canada

[3] GE Healthcare, Menlo Pk, CA USA

[4] UCSF, Dept Radiol & Biomed Imaging, San Francisco, CA USA

来源：

JOURNAL OF MAGNETIC RESONANCE | 2009年 / 200卷 / 02期

基金：

加拿大健康研究院;

关键词：

Spectral-spatial RF pulse design; Outer volume suppression; DNP; Hyperpolarized; C-13 MR metabolic imaging; MAGNETIC-RESONANCE; SPIN-ECHO; FLUX; NMR; 3T;

D O I：

10.1016/j.jmr.2009.06.021

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

[1-C-13] pyruvate pre-polarized via DNP has been used in animal models to probe changes in metabolic enzyme activities in vivo. To more accurately assess the metabolic state and its change from disease progression or therapy in a specific region or tissue in vivo, it may be desirable to separate the downstream C-13 metabolite signals resulting from the metabolic activity within the tissue of interest and those brought into the tissue by perfusion. In this study, a spectral-spatial saturation pulse that selectively saturates the signal from the metabolic products [1-C-13] lactate and [1-C-13] alanine was designed and implemented as outer volume suppression for localized MRSI acquisition. Preliminary in vivo results showed that the suppression pulse did not prevent the pre-polarized pyruvate from being delivered throughout the animal while it saturated the metabolites within the targeted saturation region. (C) 2009 Elsevier Inc. All rights reserved.

引用

页码：344 / 348

页数：5