Early Administration of Convalescent Plasma Improves Survival in Patients with Hematological Malignancies and COVID-19

被引：21

作者：

Biernat, Monika Maria ^{[1
]}

Kolasinska, Anna ^{[1
]}

Kwiatkowski, Jacek ^{[1
]}

Urbaniak-Kujda, Donata ^{[1
]}

Biernat, Pawel ^{[2
]}

Janocha-Litwin, Justyna ^{[3
]}

Szymczyk-Nuzka, Malgorzata ^{[4
]}

Bursy, Dawid ^{[2
]}

Kalicinska, Elzbieta ^{[1
]}

Simon, Krzysztof ^{[3
]}

Mazur, Grzegorz ^{[5
]}

Wrobel, Tomasz ^{[1
]}

机构：

[1] Wroclaw Med Univ, Dept & Clin Haematol Blood Neoplasms & Bone Marro, Pasteura St 4, PL-50367 Wroclaw, Poland

[2] Wroclaw Med Univ, Dept Drugs Form Technol, Borowska St 211A, PL-50556 Wroclaw, Poland

[3] Wroclaw Med Univ, Dept Infect Dis & Hepatol, Koszarowa St 5, PL-51149 Wroclaw, Poland

[4] Reg Ctr Transfus Med & Blood Bank RCTMBB W, Czerwonego Krzyza St 5-9, PL-50345 Wroclaw, Poland

[5] Wroclaw Med Univ, Dept & Clin Internal & Occupat Dis Hypertens & Cl, Borowska St 213, PL-50556 Wroclaw, Poland

来源：

VIRUSES-BASEL | 2021年 / 13卷 / 03期

关键词：

COVID-19; convalescent plasma; hematological malignancies;

D O I：

10.3390/v13030436

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The use of convalescent plasma in the treatment of COVID-19 may lead to a milder course of infection and has been associated with improved outcomes. Determining optimal treatments in high risk populations is crucial, as is the case in those with hematological malignancies. We analyzed a cohort of 23 patients with hematological malignancies and COVID-19 who had received plasma 48-72 h after the diagnosis of infection and compared it with a historical group of 22 patients who received other therapy. Overall survival in those who received convalescent plasma was significantly higher than in the historical group (p = 0.03460). The plasma-treated group also showed a significantly milder course of infection (p = 0.03807), characterized by less severe symptoms and faster recovery (p = 0.00001). In conclusion, we have demonstrated that convalescent plasma is an effective treatment and its early administration leads to clinical improvement, increased viral clearance and longer overall survival in patients with hematological malignancies and COVID-19. To our knowledge, this is the first report to analyze the efficacy of convalescent plasma in a cohort of patients with hematological malignancies.

引用

页数：8

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