TfR2 expression in human colon carcinomas

被引：28
作者：
Calzolari, Alessia [1 ]
Deaglio, Silvia [2 ,3 ]
Maldi, Elena [4 ]
Cassoni, Paola [4 ]
Malavasi, Fabio [2 ,3 ]
Testa, Ugo [1 ]
机构：
[1] Ist Super Sanita, Dept Hematol Oncol & Mol Med, I-00161 Rome, Italy
[2] Univ Turin, Sch Med, Dept Genet Biol & Biochem, Turin, Italy
[3] Univ Turin, Sch Med, CeRMS, Turin, Italy
[4] Univ Turin, Sch Med, Dept Biomed Sci, Turin, Italy
来源：
BLOOD CELLS MOLECULES AND DISEASES | 2009年 / 43卷 / 03期
关键词：
Colon cancer; Transferrin receptor; Iron metabolism; TRANSFERRIN RECEPTOR 2; MUCINOUS HISTOLOGY PREDICTS; COLORECTAL-CANCER; HEREDITARY HEMOCHROMATOSIS; HEPCIDIN EXPRESSION; SIGNAL-TRANSDUCTION; PROGNOSTIC-FACTORS; IRON-METABOLISM; IN-VIVO; PROTEIN;
D O I：
10.1016/j.bcmd.2009.08.001
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Different proteins regulate iron metabolism at the level of various tissues. Among these is a second transferrin receptor (TfR2) that seems to play a key role in the regulation of iron homeostasis. Although TfR2 expression in normal tissues is restricted at the level of the liver, we observed that TfR2 is frequently expressed in cancer cell lines. Taking advantage of this observation we investigated TfR2 expression in primary colon cancers, and showed that this receptor is expressed in about 26% of cases. TfR2 expression in colon cancer is not related to histological grade, but is preferentially associated with mucinous tumors. In colon cancer cell lines, TfR2 is localized in membrane lipid rafts, induces ERK1/ERK2 phosphorylation, when activated by its ligand transferring, and is preferentially expressed during S-M phases of the cell cycle. The presence of TfR2 on the membrane of colon cancer cells may contribute the growth advantage to these cells. (C) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：243 / 249
页数：7
相关论文
共 52 条
[1]   Modulation of iron transport proteins in human colorectal carcinogenesis [J].
Brookes, M. J. ;
Hughes, S. ;
Turner, F. E. ;
Reynolds, G. ;
Sharma, N. ;
Ismail, T. ;
Berx, G. ;
McKie, A. T. ;
Hotchin, N. ;
Anderson, G. J. ;
Iqbal, T. ;
Tselepis, C. .
GUT, 2006, 55 (10) :1449-1460
[2]   Transferrin receptor 2 protein is not expressed in normal erythroid cells [J].
Calzolari, A ;
Deaglio, S ;
Sposi, NM ;
Petrucci, E ;
Morsilli, O ;
Gabbianelli, M ;
Malavasi, F ;
Peschle, C ;
Testa, U .
BIOCHEMICAL JOURNAL, 2004, 381 :629-634
[3]   Transferrin receptor 2 is frequently expressed in human cancer cell lines [J].
Calzolari, Alessia ;
Oliviero, Isabella ;
Deaglio, Silvia ;
Mariam, Gualtiero ;
Biffoni, Mauro ;
Sposi, Nadia Maria ;
Malavasi, Fabio ;
Peschle, Cesare ;
Testa, Ugo .
BLOOD CELLS MOLECULES AND DISEASES, 2007, 39 (01) :82-91
[4]   TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway [J].
Calzolari, Alessia ;
Raggi, Carla ;
Deaglio, Silvia ;
Sposi, Nadia Maria ;
Stafsnes, Marit ;
Fecchi, Katia ;
Parolini, Isabella ;
Malavasi, Fabio ;
Peschle, Cesare ;
Sargiacomo, Massimo ;
Testa, Ugo .
JOURNAL OF CELL SCIENCE, 2006, 119 (21) :4486-4498
[5]   The gene TFR2 is mutated in a new type of haemochromatosis mapping to 7q22 [J].
Camaschella, C ;
Roetto, A ;
Cali, A ;
De Gobbi, M ;
Garozzo, G ;
Carella, M ;
Majorano, N ;
Totaro, A ;
Gasparini, P .
NATURE GENETICS, 2000, 25 (01) :14-15
[6]   Mucinous histology predicts for poor response rate and overall survival of patients with colorectal cancer and treated with first-line oxaliplatin- and/or irinotecan-based chemotherapy [J].
Catalano, V. ;
Loupakis, F. ;
Graziano, F. ;
Torresi, U. ;
Bisonni, R. ;
Mari, D. ;
Fornaro, L. ;
Baldelli, A. M. ;
Giordani, P. ;
Rossi, D. ;
Alessandroni, P. ;
Giustini, L. ;
Silva, R. R. ;
Falcone, A. ;
D'Emidio, S. ;
Fedeli, S. L. .
BRITISH JOURNAL OF CANCER, 2009, 100 (06) :881-887
[7]  
Compton C, 2000, CANCER-AM CANCER SOC, V88, P1739, DOI 10.1002/(SICI)1097-0142(20000401)88:7<1739::AID-CNCR30>3.0.CO
[8]  
2-T
[9]  
Compton CC, 2000, ARCH PATHOL LAB MED, V124, P979
[10]  
CONNELLY JH, 1991, ARCH PATHOL LAB MED, V115, P1022
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