Synthesis, structural analysis, redox properties and in vitro antitumor evaluation of half-sandwich complexes of Ru(II) with aminocoumarins

被引：18

作者：

Skoczynska, Anna ^{[1
]}

Malecka, Magdalena ^{[2
]}

Cieslak, Marcin ^{[3
]}

Kazmierczak-Baranska, Julia ^{[3
]}

Krolewska-Golinska, Karolina ^{[3
]}

Leniart, Andrzej ^{[4
]}

Budzisz, Elzbieta ^{[1
]}

机构：

[1] Med Univ Lodz, Dept Cosmet Raw Mat Chem, Fac Pharm, Ul Muszynskiego 1, PL-90151 Lodz, Poland

[2] Univ Lodz, Dept Theoret & Struct Chem, Fac Chem, Ul Pomorska 163-165, PL-90236 Lodz, Poland

[3] Polish Acad Sci, Ctr Mol & Macromol Studies, Dept Bioorgan Chem, Ul Sienkiewicza 112, PL-91403 Lodz, Poland

[4] Univ Lodz, Dept Electroanal & Electrochem, Fac Chem, Ul Tamka 12, PL-91403 Lodz, Poland

来源：

POLYHEDRON | 2017年 / 127卷

关键词：

Arene ruthenium(II) complexes; Cytotoxicity; Crystal structure; Redox properties; UV-Vis stability; COUMARIN DERIVATIVES; PHYSICOCHEMICAL CHARACTERIZATION; CISPLATIN NEPHROTOXICITY; ANTICANCER ACTIVITY; METAL-COMPLEXES; RAPTA-C; CELLS; RUTHENIUM; APOPTOSIS; DELIVERY;

D O I：

10.1016/j.poly.2017.02.011

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Five ruthenium(II) half-sandwich complexes containing arene and coumarin ligands with the general formula [Ru(arene)(L)Cl-2] or [Ru(arene)(L-2)Cl]Cl were synthesized. L: 3-aminocoumarin and 7-amino-4-methylcoumarin were used for the synthesis of complex compounds. The complexes were characterized by H-1 NMR, IR, UV-Vis spectroscopy, electrospray mass spectrometry (ESI MS), elemental analysis and cyclic voltammetry measurement. X-ray crystallography found one molecular structure to be of pseudo-octahedral geometry. All compounds were also tested on Chronic Myelogenous Leukemia (K562), Human Cervix Carcinoma (HeLa), Human Pancreatic Carcinoma (CFPAC) cancer cell lines, and the viability of cells was evaluated by MTT assay. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：307 / 314

页数：8

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