The significance of left ventricular ejection time in heart failure with reduced ejection fraction

被引：42
作者：
Alhakak, Alia S. [1 ]
Teerlink, John R. [2 ,3 ]
Lindenfeld, Joann [4 ]
Boehm, Michael [5 ]
Rosano, Giuseppe M. C. [6 ]
Biering-Sorensen, Tor [7 ]
机构：
[1] Univ Copenhagen, Herlev & Gentofte Hosp, Dept Cardiol, Copenhagen, Denmark
[2] Univ Calif San Francisco, San Francisco Vet Affairs Med Ctr, Sect Cardiol, San Francisco, CA 94143 USA
[3] Univ Calif San Francisco, Sch Med, San Francisco, CA USA
[4] Vanderbilt Univ, Med Ctr, Nashville, TN USA
[5] Saarland Univ, Univ Klinikum Saarlandes, Klin Innere Med 3, Dept Internal Med, Homburg, Germany
[6] IRCCS San Raffaele Pisana, Dept Med Sci, Rome, Italy
[7] Univ Copenhagen, Fac Hlth & Med Sci, Dept Biomed Sci, Copenhagen, Denmark
来源：
EUROPEAN JOURNAL OF HEART FAILURE | 2021年 / 23卷 / 04期
关键词：
Left ventricular ejection time; Heart failure; Myotropes; Contractility; Outcomes; CARDIAC MYOSIN ACTIVATOR; MYOCARDIAL PERFORMANCE INDEX; M-MODE ECHOCARDIOGRAPHY; IMAGING M-MODE; OMECAMTIV MECARBIL; INCREASE CONTRACTILITY; INTERVALS; MECHANISMS; RISK; CARVEDILOL;
D O I：
10.1002/ejhf.2125
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET. [GRAPHICS]
引用
收藏
页码：541 / 551
页数：11
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