Primary central nervous system lymphoma

被引：18

作者：

Abrey, Lauren E. ^{[1
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Neurol, New York, NY 10065 USA

来源：

CURRENT OPINION IN NEUROLOGY | 2009年 / 22卷 / 06期

关键词：

chemotherapy; molecular genetic characteristics; primary central nervous system lymphoma; treatment; PRIMARY-CNS-LYMPHOMA; OCCULT LEPTOMENINGEAL DISEASE; B-CELL LYMPHOMAS; FDG-PET; INTRAOCULAR LYMPHOMA; COGNITIVE FUNCTIONS; SALVAGE THERAPY; GENE-EXPRESSION; FLOW-CYTOMETRY; PHASE-II;

D O I：

10.1097/WCO.0b013e328332533b

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Purpose of review This review will summarize recent advances in the understanding and treatment of primary central nervous system lymphoma (PCNSL). Recent findings The molecular and genetic characteristics that distinguish PCNSL are beginning to be elucidated. New tools such as flow cytometry and PET are improving the diagnosis and management of PCNSL. Although the current standard of care is high-dose methotrexate-based chemotherapy alone or in combination with whole brain radiotherapy, multiple questions remain regarding the optimal treatment of PCNSL, in general, and unusual variants of PCNSL. Summary Although recent advances have improved our understanding of PCNSL, the need for additional collaborative research is critical.

引用

页码：675 / 680

页数：6

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