Perceptions of pharmacogenetic research to guide tobacco cessation by patients, providers and leaders in a tribal healthcare setting

被引：17

作者：

Avey, Jaedon P. ^{[1
]}

Hiratsuka, Vanessa Y. ^{[1
]}

Beans, Julie A. ^{[1
]}

Trinidad, Susan Brown ^{[2
]}

Tyndale, Rachel F. ^{[3
,4
]}

Robinson, Renee F. ^{[1
]}

机构：

[1] Southcent Fdn, Res Dept, 4105 Tudor Ctr Dr, Anchorage, AK 99508 USA

[2] Univ Washington, Dept Bioeth & Humanities, Box 357120, Seattle, WA 98195 USA

[3] Univ Toronto, Dept Psychiat, Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Med Sci Bldg Room 4326,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

[4] Univ Toronto, Dept Pharmacol & Toxicol, Ctr Addict & Mental Hlth, Campbell Family Mental Hlth Res Inst, Med Sci Bldg Room 4326,1 Kings Coll Circle, Toronto, ON M5S 1A8, Canada

来源：

PHARMACOGENOMICS | 2016年 / 17卷 / 04期

关键词：

academic-community partnership; American Indian/Alaska Native; community-based participatory research; genetic research; pharmacogenetics; tobacco cessation; ALASKA NATIVE PEOPLE; SMOKING-CESSATION; AMERICAN-INDIANS; PERSPECTIVES; POLYMORPHISM; PARTNERSHIP; VARENICLINE; BUPROPION; MEDICINE; SCIENCE;

D O I：

10.2217/pgs.15.177

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Aim: Describe patients,'providers' and healthcare system leaders' perceptions of pharmacogenetic research to guide tobacco cessation treatment in an American Indian/Alaska Native primary care setting. Materials & methods: This qualitative study used semistructured interviews with 20 American Indian/Alaska Native current or former tobacco users, 12 healthcare providers and nine healthcare system leaders. Results: Participants supported pharmacogenetic research to guide tobacco cessation treatment provided that a community-based participatory research approach be employed, research closely coordinate with existing tobacco cessation services and access to pharmacogenetic test results be restricted to providers involved in tobacco cessation. Conclusion: Despite a history of mistrust toward genetic research in tribal communities, participants expressed willingness to support pharmacogenetic research to guide tobacco cessation treatment.

引用

页码：405 / 415

页数：11

共 47 条

[1]

Alaska Department of Health and Social Services, 2007, WHAT STAT SURV TELL

[2]

[Anonymous], RES 2013 NAT SURV DR

[3]

Attride-Stirling J., 2001, Qualitative Research, V1, P385, DOI [DOI 10.1177/146879410100100307, 10.1177/146879410100100307]

[4] Ethical Issues in Developing Pharmacogenetic Research Partnerships With American Indigenous Communities [J].

Boyer, B. B. ;

Dillard, D. ;

Woodahl, E. L. ;

Whitener, R. ;

Thummel, K. E. ;

Burke, W. .

CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (03) :342-345

[5] Sharing results from complex disease genetics studies: A community based participatory research approach [J].

Boyer, Bert B. ;

Mohatt, Gerald V. ;

Pasker, Renee L. ;

Drew, Elaine M. ;

McGlone, Kathleen K. .

INTERNATIONAL JOURNAL OF CIRCUMPOLAR HEALTH, 2007, 66 (01) :19-30

[6] Genomics and personalized medicine: CHRNA5-CHRNA3-CHRNB4 and smoking cessation treatment [J].

Chen, Li-Shiun ;

Bierut, Laura J. .

JOURNAL OF FOOD AND DRUG ANALYSIS, 2013, 21 :S87-S90

[7] Culturally-Tailored Smoking Cessation for American Indians: Study protocol for a randomized controlled trial [J].

Choi, Won S. ;

Faseru, Babalola ;

Beebe, Laura A. ;

Greiner, Allen K. ;

Yeh, Hung-Wen ;

Shireman, Theresa I. ;

Talawyma, Myrietta ;

Cully, Lance ;

Kaur, Baljit ;

Daley, Christine M. .

TRIALS, 2011, 12

[8]

Creswell J.W., 2011, Designing and Conducting Mixed Methods Research

[9] Evaluation of a Tailored Approach for Tobacco Dependence Treatment for American Indians [J].

D'Silva, Joanne ;

Schillo, Barbara A. ;

Sandman, Nathan R. ;

Leonard, Theresa L. ;

Boyle, Raymond G. .

AMERICAN JOURNAL OF HEALTH PROMOTION, 2011, 25 (05) :S66-S69

[10] Process and Outcomes of Patient-Centered Medical Care With Alaska Native People at Southcentral Foundation [J].

Driscoll, David L. ;

Hiratsuka, Vanessa ;

Johnston, Janet M. ;

Norman, Sara ;

Reilly, Katie M. ;

Shaw, Jennifer ;

Smith, Julia ;

Szafran, Quenna N. ;

Dillard, Denise .

ANNALS OF FAMILY MEDICINE, 2013, 11 :S41-S49

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