Quaternary Phosphonium Salts as Active Bronsted Acid Catalysts for Friedel-Crafts Reactions

被引：25

作者：

Chen, Lin ^{[1
,2
]}

Xiao, Ben-Xian ^{[1
,2
]}

Du, Wei ^{[1
,2
]}

Chen, Ying-Chun ^{[1
,2
,3
]}

机构：

[1] Sichuan Univ, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Sichuan, Peoples R China

[2] Sichuan Univ, West China Sch Pharm, Sichuan Res Ctr Drug Precis Ind Technol, Chengdu 610041, Sichuan, Peoples R China

[3] Third Mil Med Univ, Coll Pharm, Chongqing 400038, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 14期

关键词：

ISATIN-DERIVED KETIMINES; ACETONYLTRIPHENYLPHOSPHONIUM BROMIDE; ORGANIC-SYNTHESIS; DEPROTECTION; PROTECTION; ALCOHOLS; DESIGN; WITTIG;

D O I：

10.1021/acs.orglett.9b02108

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A readily available quaternary phosphonium salt containing a trifluoroacetonyl group and a tetrakis[3,5-bis(trifluoromethyl)phenyl]borate (BAr4F-) counterion was demonstrated to be a highly active Bronsted acid catalyst for Friedel Crafts-type reactions of an array of electron-rich heteroarenes and aniline derivatives with isatin-derived ketimines, even at 0.1 mol % catalyst loadings.

引用

页码：5733 / 5736

页数：4

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