Cation Tuning of Supramolecular Gel Properties: A New Paradigm for Sustained Drug Delivery

被引：65
|
作者：
Ramin, Michael A. [1 ]
Sindhu, Kotagudda Ranganath [2 ]
Appavoo, Ananda [1 ]
Oumzil, Khalid [1 ]
Grinstaff, Mark W. [3 ]
Chassande, Olivier [2 ]
Barthelemy, Philippe [1 ]
机构：
[1] Univ Bordeaux, ARNA Lab, U1212, CNRS 5320, Bordeaux F-33000, France
[2] Univ Bordeaux, INSERM, U1026, Bordeaux F-33000, France
[3] Boston Univ, Dept Biomed Engn & Chem, Boston, MA 02215 USA
来源：
ADVANCED MATERIALS | 2017年 / 29卷 / 13期
关键词：
NUCLEOSIDE LIPIDS; NUCLEIC-ACID; ASSEMBLIES; HYDROGELS; NANOPARTICLES; NUCLEOLIPIDS; AMPHIPHILES; TRANSITION; NUCLEOTIDE; SURFACTANT;
D O I：
10.1002/adma.201605227
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Hydrogels formed by the self-assembly of low-molecular-weight gelators (LMWGs) are promising scaffolds for drug-delivery applications. A new biocompatible hydrogel, resulting from the self-assembly of nucleotide-lipid salts can be safely injected in vivo. The resulting hydrogel provides sustained-release of protein for more than a week.
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页数：6
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