Jak1 kinase is required for cell migrations and anterior specification in zebrafish embryos

被引：46

作者：

Conway, G ^{[1
]}

Margoliath, A ^{[1
]}

WongMadden, S ^{[1
]}

Roberts, RJ ^{[1
]}

Gilbert, W ^{[1
]}

机构：

[1] NEW ENGLAND BIOLABS INC,BEVERLY,MA 01915

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1997年 / 94卷 / 07期

关键词：

D O I：

10.1073/pnas.94.7.3082

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Establishment of the vertebrate body plan requires a variety of signaling molecules. In a search for tyrosine kinases expressed in early zebrafish embryos, a model system for the study of vertebrate development, we discovered Jak1 kinase to be maternally encoded and the mRNA evenly distributed among the cells of blastula-stage embryos. Injection of RNA-encoding dominant-negative Jak1 kinases reduces a specific cell migration, epiboly, and results in the reduction of goosecoid expression and of anterior structures. This work establishes that. In addition to its role in signal transduction of cytokines in adult tissues, Jak1 kinase has a role in early vertebrate development.

引用

页码：3082 / 3087

页数：6

共 36 条

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