Assessing the Completeness of Reporting in Preclinical Oncolytic Virus Therapy Studies

被引：14

作者：

Fergusson, Dean A. ^{[1
,2
]}

Wesch, Neil L. ^{[1
]}

Leung, Garvin J. ^{[1
,2
]}

MacNeil, Jenna L. ^{[1
]}

Conic, Isidora ^{[1
]}

Presseau, Justin ^{[1
,3
]}

Cobey, Kelly D. ^{[3
,4
,5
]}

Diallo, Jean-Simon ^{[6
,7
]}

Auer, Rebecca ^{[2
,6
,7
]}

Kimmelman, Jonathan ^{[8
]}

Kekre, Natasha ^{[2
]}

El-Sayes, Nader ^{[2
,6
]}

Krishnan, Ramya ^{[2
,6
]}

Keller, Brian A. ^{[2
,6
]}

Ilkow, Carolina ^{[6
,7
]}

Lalu, Manoj M. ^{[1
,9
,10
,11
]}

机构：

[1] Ottawa Hosp Res Inst, BLUEPRINT Translat Res Grp, Clin Epidemiol Program, 501 Smyth Rd,POB 201B, Ottawa, ON K1H 8L6, Canada

[2] Univ Ottawa, Fac Med, Ottawa, ON K1H 8M5, Canada

[3] Univ Ottawa, Sch Epidemiol & Publ Hlth, Ottawa, ON K1H 8M5, Canada

[4] Ottawa Hosp Res Inst, Ctr Journalol, Ottawa, ON K1H 8L6, Canada

[5] Univ Stirling, Dept Psychol, Stirling FK9 4LA, Scotland

[6] Ottawa Hosp Res Inst, Canc Therapeut Program, Ottawa, ON K1H 8L6, Canada

[7] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

[8] McGill Univ, Biomed Eth Unit, Montreal, PQ H3A 0G4, Canada

[9] Ottawa Hosp Res Inst, Regenerat Med Program, Ottawa, ON K1H 8L6, Canada

[10] Univ Ottawa, Ottawa Hosp, Dept Anesthesiol & Pain Med, Ottawa, ON K1H 8L6, Canada

[11] Univ Ottawa, Dept Cellular & Mol Med, Ottawa, ON K1H 8M5, Canada

来源：

MOLECULAR THERAPY-ONCOLYTICS | 2019年 / 14卷

关键词：

DESIGN AFFECTS OUTCOMES; CANCER; METAANALYSIS; VIROTHERAPY;

D O I：

10.1016/j.omto.2019.05.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Irreproducibility of preclinical findings could be a significant barrier to the "bench-to-bedside" development of oncolytic viruses (OVs). A contributing factor is the incomplete and non-transparent reporting of study methodology and design. Using the NIH Principles and Guidelines for Reporting Preclinical Research, a core set of seven recommendations, we evaluated the completeness of reporting of preclinical OV studies. We also developed an evidence map identifying the current trends in OV research. A systematic search of MEDLINE and Embase identified all relevant articles published over an 18 month period. We screened 1,554 articles, and 236 met our a priori-defined inclusion criteria. Adenovirus (43%) was the most commonly used viral platform. Frequently investigated cancers included colorectal (14%), skin (12%), and breast (11%). Xenograft implantation (61%) in mice (96%) was the most common animal model. The use of preclinical reporting guidelines was listed in 0.4% of articles. Biological and technical replicates were completely reported in 1% of studies, statistics in 49%, randomization in 1%, blinding in 2%, sample size estimation in 0%, and inclusion/exclusion criteria in 0%. Overall, completeness of reporting in the preclinical OV therapy literature is poor. This may hinder efforts to interpret, replicate, and ultimately translate promising preclinical OV findings.

引用

页码：179 / 187

页数：9