A Cascade Approach to Captodative Trifluoromethylated Enamines or Vinylogous Guanidinium Salts: Aromatic Substituents as Switches of Reaction Direction

被引：25

作者：

Rulev, Alexander Yu. ^{[1
]}

Muzalevskiy, Vasiliy M. ^{[2
]}

Kondrashov, Evgeniy V. ^{[1
]}

Ushakov, Igor A. ^{[1
]}

Shastin, Aleksey V. ^{[3
]}

Balenkova, Elizabeth S. ^{[2
]}

Haufe, Guenter ^{[4
]}

Nenajdenko, Valentine G. ^{[2
]}

机构：

[1] Russian Acad Sci, Siberian Branch, AE Favorsky Inst Chem, Irkutsk 664033, Russia

[2] Moscow MV Lomonosov State Univ, Dept Chem, Moscow 119992, Russia

[3] Inst Problems Chem Phys, Chernogolovka 142432, Moscow Region, Russia

[4] Univ Munster, Inst Organ Chem, D-48149 Munster, Germany

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 02期

基金：

俄罗斯基础研究基金会;

关键词：

Amines; Nucleophilic substitution; Domino reactions; STEREOSELECTIVE-SYNTHESIS; CATALYTIC OLEFINATION; EFFICIENT SYNTHESIS; SYNTHETIC APPROACH; ENOL ETHERS; KETONES; AMINES; ALDEHYDES;

D O I：

10.1002/ejoc.200900926

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

beta-Halo-beta-(trifluoromethyl)styrenes readily react with a variety of nitrogen nucleophiles bearing primary amino groups to afford either the captodative trifluoromethylated enamines or vinylogous guanidinium salts in a selective fashion depending on the electronic natures of the aromatic substituents.

引用

页码：300 / 310

页数：11

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