Serum Exosomal lncRNA DLX6-AS1 Is a Promising Biomarker for Prognosis Prediction of Cervical Cancer

被引:36
作者
Ding, Xian-zhen [1 ]
Zhang, Shi-qiang [2 ]
Deng, Xiao-lan [2 ]
Qiang, Jin-hu [2 ]
机构
[1] Wuxi Xishan Hosp, Dept Gynaecol & Obstet, Wuxi, Jiangsu, Peoples R China
[2] Wuxi Xishan Hosp, Dept Oncol, 1128 Dacheng Rd, Wuxi, Jiangsu, Peoples R China
关键词
exosomes; DLX6-AS1; cervical cancer; biomarker; diagnosis; INHIBITS CELL-PROLIFERATION; LONG NONCODING RNAS; PROMOTES; INVASION; STATISTICS; MIGRATION; KNOCKDOWN; GROWTH;
D O I
10.1177/1533033821990060
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Objective: Deregulation of long noncoding RNAs (lncRNAs) is involved in the initiation and progression of cancer. LncRNA DLX6-AS1 is regarded as an oncogene in many cancer types. However, the clinical role of serum exosomal lncRNA DLX6-AS1 in cervical cancer (CC) is poorly known. This study aimed to analyze the diagnostic and prognostic value of serum exosomal lncRNA DLX6-AS1 in CC. Methods: A total of 114 patients with CC, 60 patients with CIN (cervical intraepithelial neoplasia), and 110 healthy women were enrolled in this study. Real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was performed to measure the serum exosomal lncRNA DLX6-AS1 levels in all participants. Results: Serum exosomal lncRNA DLX6-AS1 level was significantly elevated in CC patients compared with CIN patients and normal controls. In addition, high serum exosomal lncRNA DLX6-AS1 expression was positively associated with lymph node metastasis, differentiation, FIGO stage, and shortened survival. Patients with high serum exosomal lncRNA DLX6-AS1 expression were more prone to have a relapse. Furthermore, univariate and multivariate analyses suggested that serum exosomal lncRNA DLX6-AS1 was a potential prognostic indicator for overall survival of CC patients. Conclusions: These findings demonstrated that serum lncRNA DLX6-AS1 might serve as a promising marker for the diagnosis and prognosis prediction of CC.
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页数:6
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