Pyoverdine siderophores: from biogenesis to biosignificance

被引：399
作者：
Visca, Paolo
Imperi, Francesco
Lamont, Iain L. [1 ]
机构：
[1] Univ Rome Tre, Dept Biol, I-00146 Rome, Italy
[2] Natl Inst Infect Dis L Spallanzani, Mol Microbiol Unit, I-00149 Rome, Italy
[3] Univ Otago, Dept Biochem, Dunedin 9054, New Zealand
来源：
TRENDS IN MICROBIOLOGY | 2007年 / 15卷 / 01期
关键词：
D O I：
10.1016/j.tim.2006.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Pyoverdines are a group of structurally related siderophores produced by fluorescent Pseudomonas species. Recent genomic and biochemical data have shed new light on the complex molecular steps of pyoverdine biogenesis and explained the chemical diversity of these compounds. In the opportunistic pathogen Pseudomonas aeruginosa, pyoverdine is necessary for infection in several different disease models. The occurrence of pyoverdine-defective strains in chronic infections of patients with cystic fibrosis and the extremely high sequence diversity of genes involved in pyoverdine synthesis and uptake indicate that pyoverdine production is subject to high evolutionary pressure. Pyoverdine-dependent iron transport is also crucial for biofilm development, further expanding the importance of these siderophores in Pseudomonas biology.
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页码：22 / 30
页数：9
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