Proportion and mortality of Iranian diabetes mellitus, chronic kidney disease, hypertension and cardiovascular disease patients with COVID-19: a meta-analysis

被引:21
作者
Mirjalili, Hamid [1 ]
Dastgheib, Seyed Alireza [2 ]
Shaker, Seyed Hossein [3 ]
Bahrami, Reza [4 ]
Mazaheri, Mahta [5 ,6 ]
Sadr-Bafghi, Seyed Mohamad Hossein [7 ]
Sadeghizadeh-Yazdi, Jalal [8 ]
Neamatzadeh, Hossein [5 ,6 ]
机构
[1] Shahid Sadoughi Univ Med Sci, Dept Emergency Med, Yazd, Iran
[2] Shiraz Univ Med Sci, Sch Med, Dept Med Genet, Shiraz, Iran
[3] Iran Univ Med Sci, Dept Emergency Med, Tehran, Iran
[4] Shiraz Univ Med Sci, Neonatal Res Ctr, Shiraz, Iran
[5] Shahid Sadoughi Univ Med Sci, Mother & Newborn Hlth Res Ctr, Yazd, Iran
[6] Shahid Sadoughi Univ Med Sci, Dept Med Genet, Yazd, Iran
[7] Islamic Azad Univ, Yazd Branch, Dept Cardiol, Yazd, Iran
[8] Shahid Sadoughi Univ Med Sci, Sch Publ Hlth, Dept Food Sci & Technol, Yazd, Iran
关键词
SARS-COV-2; COVID-19; Diabetes; Chronic kidney disease; Hypertension; Cardiovascular disease; RISK-FACTORS; INFECTION; SEVERITY; SARS-COV-2; OUTCOMES; TYPE-1;
D O I
10.1007/s40200-021-00768-5
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background Currently, the number of patients with SARS-COV-2 infection has increased rapidly in Iran, but the risk and mortality of SARS-COV-2 infection in Iranian patients with diabetes mellitus (DM), chronic kidney disease (CKD), hypertension and cardiovascular diseases (CVDs) still not clear. The aim of this meta-analysis was to estimate the proportion and mortality of SARS-COV-2 in these patients. Methods A comprehensive literature search was carried out in PubMed, Web of Sciences, Cochrane Library, EMBASE, CNKI, SciELO, and other databases to identify all relevant studies published up to 10 January, 2020. The proportion and mortality in the patients were assessed by odd ratio (OR) and the corresponding 95 % confidence interval (95 % CI). Results A total of ten case-series including 11,755 cases with SARS-COV-2 infection and 942 deaths were selected. Among them, there were total of 791 DM patients with 186 deaths, 225 CKD patients with 45 deaths, 790 hypertension cases with 86 deaths, and 471 CVDs cases with 60 deaths. Pooled data revealed that the proportion of SARS-COV-2 infection in the patients with hypertension, DM, CVDs and CKD were 21.1 %, 16.3 %, 14.0 % and 5.0 %, respectively. Moreover, the SARS-COV-2 infection were associated with an increased risk of mortality in DM (OR = 0.549, CI 95 % 0.448-0.671, p <= 0.001) and CKD (OR = 0.552, 95 % CI 0.367-0.829, p = 0.004) patients, but not hypertension and CVDs. There was no publication bias. Conclusions Our pooled data showed that the proportion of SARS-COV-2 infection was the highest in the Iranian patients with hypertension (21.1 %) followed by DM (16.3 %), CVDs (14.0 %) and CKD (5.0 %). Moreover, DM and CKD in patients with SARS-COV-2 infection were associated with a 0.549 and 0.552-fold increase in mortality, respectively. Clinicians in Iran should be aware of these findings, to identifying patients at higher risk and inform interventions to reduce the risk of death. Moreover, well-designed, large-scale and multicenter studies are needed to improve and validate our findings.
引用
收藏
页码:905 / 917
页数:13
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