Early Events Triggering the Initiation of a Type 2 Immune Response

被引：22
作者：
El-Naccache, Darine W. [1 ,2 ]
Hasko, Gyorgy [3 ]
Gause, William C. [1 ,2 ]
机构：
[1] Rutgers New Jersey Med Sch, Ctr Immun & Inflammat, Newark, NJ 07103 USA
[2] Rutgers New Jersey Med Sch, Dept Med, Newark, NJ 07103 USA
[3] Columbia Univ, Dept Anesthesiol, New York, NY 10032 USA
来源：
TRENDS IN IMMUNOLOGY | 2021年 / 42卷 / 02期
基金：
美国国家卫生研究院;
关键词：
allergens; cancer; DAMPs; helminths; sterile inflammation;
D O I：
10.1016/j.it.2020.11.006
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Type 2 immune responses are typically associated with protection against helminth infections and also with harmful inflammation in response to allergens. Recent advances have revealed that type 2 immunity also contributes to sterile inflammation, cancer, and microbial infections. However, the early events that initiate type 2 immune responses remain poorly defined. New insights reveal major contributions from danger-associated molecular patterns (DAMPs) in the initiation of type 2 immune responses. In this review, we examine the molecules released by the host and pathogens and the role they play in mediating the initiation of mammalian innate type 2 immune responses under a variety of conditions.
引用
收藏
页码：151 / 164
页数：14
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