Anti-inflammatory activity of two varieties of pumpkin seed oil in an adjuvant arthritis model in rats

被引：15
作者：
Al-Okbi, S. Y. [1 ]
Mohamed, D. A. [1 ]
Kandil, E. [2 ]
Abo-Zeid, M. A. [3 ]
Mohammed, S. E. [1 ]
Ahmed, E. K. [2 ]
机构：
[1] Natl Res Ctr, Dept Food Sci & Nutr, Cairo, Egypt
[2] Ain Shams Univ, Fac Sci, Dept Biochem, Cairo, Egypt
[3] Natl Res Ctr, Genet & Cytol Dept, Cairo, Egypt
来源：
GRASAS Y ACEITES | 2017年 / 68卷 / 01期
关键词：
Adjuvant arthritis; Anti-inflammatory; beta-Carotene; Phenolic contents; Pumpkin seed oils; RHEUMATOID-ARTHRITIS; DISEASE; LIVER; FOODS; ACID;
D O I：
10.3989/gya.0796161
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
The aim of the present research was to evaluate the anti-inflammatory activity of pumpkin seed oils (PSOs) of an Egyptian and European variety, in a rat model of adjuvant arthritis. Edema thickness, plasma tumor necrosis factor-alpha (TNF-alpha) and erythrocyte sedimentation rate (ESR) were determined as inflammatory biomarkers while malondialdehyde (MDA) and total antioxidant capacity (TAC) were assessed as indicative of oxidative stress. Chromosomal aberration, sperm shape abnormalities, and DNA fragmentations are cytogenetic parameters which aid in tracing inflammatory and oxidative activity. Phenolic contents and beta-carotene were determined in PSOs. The results showed elevated ESR, plasma TNF-alpha, plasma MDA, liver cellular DNA fragmentation, bone marrow chromosomal aberration, sperm shape abnormalities with a reduction in plasma TAC and body weight gain in an adjuvant arthritis control compared to a healthy control. Administration of low and high doses of either Egyptian or European PSO improved all the aforementioned parameters with variable degrees.
引用
收藏
页数：12
相关论文
共 36 条
  • [1] Functional ingredients and cardiovascular protective effect of pumpkin seed oils
    Al-Okbi, S. Y.
    Mohamed, D. A.
    Kandil, E.
    Ahmed, E. K.
    Mohammed, S. E.
    [J]. GRASAS Y ACEITES, 2014, 65 (01)
  • [2] Preparation and evaluation of functional foods in adjuvant arthritis
    Al-Okbi, S. Y.
    Mohamed, D. A.
    [J]. GRASAS Y ACEITES, 2012, 63 (04) : 394 - 402
  • [3] Role of Bifidobacterium bifidum and plant food extracts in improving microflora and biochemical and cytogenetic parameters in adjuvant arthritis
    Al-Okbi, S. Y.
    Mohamed, D. A.
    Donya, S. M.
    Abd El Khalek, A. B.
    [J]. GRASAS Y ACEITES, 2011, 62 (03) : 308 - 320
  • [4] Al-Okbi SY, 2000, KASR EL AINI MED J, V6, P43
  • [5] Rheumatoid Arthritis Disease Activity Measures: American College of Rheumatology Recommendations for Use in Clinical Practice
    Anderson, Jaclyn
    Caplan, Liron
    Yazdany, Jinoos
    Robbins, Mark L.
    Neogi, Tuhina
    Michaud, Kaleb
    Saag, Kenneth G.
    O'Dell, James R.
    Kazi, Salahuddin
    [J]. ARTHRITIS CARE & RESEARCH, 2012, 64 (05) : 640 - 647
  • [6] Comparison between free radical scavenging capacity and oxidative stability of nut oils
    Arranz, Sara
    Cert, Rosa
    Perez-Jimenez, Jara
    Cert, Arturo
    Saura-Calixto, Fulgendo
    [J]. FOOD CHEMISTRY, 2008, 110 (04) : 985 - 990
  • [7] Combination of carvacrol with methotrexate suppresses Complete Freund's Adjuvant induced synovial inflammation with reduced hepatotoxicity in rats
    Banji, Otilia J. F.
    Banji, David
    Soumya, N.
    Chilipi, Kiran Kumar
    Kalpana, C. H.
    Kumar, C. H. Kranthi
    Annamalai, A. R.
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2014, 723 : 91 - 98
  • [8] Polyphenols, antioxidants, and antimutagenic effects of Copaifera langsdorffii fruit
    Batista, Angela Giovana
    Ferrari, Angelica Simoes
    da Cunha, Debora Cristina
    da Silva, Juliana Kelly
    Betim Cazarin, Cinthia Bau
    Correa, Luiz Claudio
    Prado, Marcelo Alexandre
    de Carvalho-Silva, Luciano Bruno
    Esteves, Elizabethe Adriana
    Marostica Junior, Mario Roberto
    [J]. FOOD CHEMISTRY, 2016, 197 : 1153 - 1159
  • [9] Amino acid, mineral and fatty acid content of pumpkin seeds (Cucurbita spp) and Cyperus esculentus nuts in the Republic of Niger
    Glew, R. H.
    Glew, R. S.
    Chuang, L. -T.
    Huang, Y. -S.
    Millson, M.
    Constans, D.
    Vanderjagt, D. J.
    [J]. PLANT FOODS FOR HUMAN NUTRITION, 2006, 61 (02) : 51 - 56
  • [10] Goldring SR, 2000, ANN RHEUM DIS, V59, P72
1234