Pharmacology in cerebrovascular disease research: Pharmacokinetics-pharmacodynamics to the rescue

被引：0

作者：

Feuerstein, Giora Z. ^{[1
]}

机构：

[1] FARMACON LLC, Translat Med Consulting, 540 Hoffman Dr, Bryn Mawr, PA 19010 USA

来源：

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2016年 / 36卷 / 03期

关键词：

Translational research; drug discovery; pharmacokinetics; pharmacodynamics; stroke; brain ischemia; drug trials;

D O I：

10.1177/0271678X15619429

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Pharmacological tools (compounds) have an important role in validation of biological molecular targets for their role in disease processes and their prospective development for therapeutic objectives. Effective utilization of such pharmacological tools impacts on the veracity of the information by which decisions regarding target validation is reached, and investment in clinical development is committed. This commentary addresses frequent gaps in effective utilization of pharmacological principles and practices of pharmacokinetics and pharmacodynamics in experimental pre-clinical research, which if more rigorously implemented could contribute to eventual success in drug development for stroke and neurotrauma.

引用

页码：639 / 644

页数：6

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