Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response

被引:548
|
作者
Garlanda, C
Hirsch, E
Bozza, S
Salustri, A
De Acetis, M
Nota, R
Maccagno, A
Riva, F
Bottazzi, B
Peri, G
Doni, A
Vago, L
Botto, M
De Santis, R
Carminati, P
Siracusa, G
Altruda, F
Vecchi, A
Romani, L
Mantovani, A
机构
[1] Mario Negri Inst Pharmacol Res, Dept Immunol & Cell Biol, I-20157 Milan, Italy
[2] Univ Turin, Dept Genet Biol & Biochem, Turin, Italy
[3] Univ Perugia, Dept Expt Med & Biochem Sci, Microbiol Sect, I-06100 Perugia, Italy
[4] Univ Roma Tor Vergata, Dept Publ Hlth & Cell Biol, Rome, Italy
[5] Univ Milan, Osped Luigi Sacco, Inst Pathol, Milan, Italy
[6] Imperial Coll Sch Med, Hammersmith Hosp, Div Med, Rheumatol Sect, London, England
[7] SigmaTau SpA, Rome, Italy
[8] Univ Milan, Inst Gen Pathol, Ctr IDET, Milan, Italy
关键词
D O I
10.1038/nature01195
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Pentraxins are a superfamily of conserved proteins that are characterized by a cyclic multimeric structure(1). The classical short pentraxins, C-reactive protein (CRP) and serum amyloid P component (SAP), are acute-phase proteins produced in the liver in response to inflammatory mediators(2-4). Short pentraxins regulate innate resistance to microbes and the scavenging of cellular debris and extracellular matrix components(2-5). In contrast, long pentraxins have an unrelated, long amino-terminal domain coupled to the carboxy-terminal pentraxin domain, and differ, with respect to short pentraxins, in their gene organization, chromosomal localization, cellular source, and in their stimuli-inducing and ligand-recognition ability(6). To investigate the in vivo function of the long pentraxin PTX3, we generated mice deficient in Ptx3 by homologous recombination. Ptx3-null mice were susceptible to invasive pulmonary aspergillosis. Ptx3 binds selected microbial agents, including conidia of Aspergillus fumigatus, and we found that susceptibility of Ptx3-null mice was associated with defective recognition of conidia by alveolar macrophages and dendritic cells, as well as inappropriate induction of an adaptive type 2 response. Thus, the long pentraxin Ptx3 is a secreted pattern-recognition receptor that has a non-redundant role in resistance to selected microbial agents, in particular to the opportunistic fungal pathogen Aspergillus fumigatus.
引用
收藏
页码:182 / 186
页数:5
相关论文
共 45 条
  • [41] Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages
    Marelli, G.
    Belgiovine, C.
    Mantovani, A.
    Erreni, M.
    Allavena, P.
    IMMUNOBIOLOGY, 2017, 222 (02) : 463 - 472
  • [42] Role of a novel long non-coding RNA in innate immune response to influenza virus infection.
    Hu, J.
    Liao, Y.
    Chen, J.
    MOLECULAR BIOLOGY OF THE CELL, 2018, 29 (26)
  • [43] Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66(ShcA) in pacemaker-implanted patients
    Bosutti, A.
    Grassi, G.
    Zanetti, M.
    Aleksova, A.
    Zecchin, M.
    Sinagra, G.
    Biolo, G.
    Guarnieri, G.
    CLINICAL AND EXPERIMENTAL MEDICINE, 2007, 7 (01) : 16 - 23
  • [44] Relation between the plasma levels of LDL-cholesterol and the expression of the early marker of inflammation long pentraxin PTX3 and the stress response gene p66(ShcA) in pacemaker-implanted patients
    A. Bosutti*
    G. Grassi*
    M. Zanetti
    A. Aleksova
    M. Zecchin
    G. Sinagra
    G. Biolo
    G. Guarnieri
    Clinical and Experimental Medicine, 2007, 7 : 16 - 23
  • [45] Pivotal role for the non-receptor tyrosine kinase SRMS in IRF3-dependent innate antiviral immune response in murine cells
    Wang, Ruixue
    Zhang, Yunzhi
    Li, Nan L.
    Yang, Darong
    Wang, Dang
    Zhou, Zhi
    Potts, Malia B.
    Li, Kui
    JOURNAL OF IMMUNOLOGY, 2023, 210 (01):