Multimodal dementia prevention - does trial design mask efficacy?

被引：5

作者：

Scarmeas, Nikolaos ^{[1
,2
,3
]}

机构：

[1] Univ Athens, Dept Social Med Psychiat & Neurol, 72 Vasilisis Sofias Ave, Athens 11528, Greece

[2] Columbia Univ, Med Ctr, Taub Inst Res Alzheimers Dis, Sergievsky Ctr, 622 West 168th St,PH 19th Floor, New York, NY 10032 USA

[3] Columbia Univ, Med Ctr, Aging Brain,Gertrude H Sergievsky Ctr, Sergievsky Ctr,Dept Neurol, 622 West 168th St,PH 19th Floor, New York, NY 10032 USA

来源：

NATURE REVIEWS NEUROLOGY | 2017年 / 13卷 / 06期

关键词：

INTERVENTION;

D O I：

10.1038/nrneurol.2017.73

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The first large trial of a multimodal lifestyle intervention combined with a nutritional supplement for dementia prevention was unsuccessful and adds to conflicting evidence from similar studies. Whether lifestyle interventions are biologically ineffective or whether the lack of efficacy is due to methodological limitations remains to be determined.

引用

页码：323 / 324

页数：2

共 4 条

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