The impact of body mass index and Helicobacter pylori infection on gastro-oesophageal reflux symptoms: A population-based study in Northern Norway

被引:34
作者
Breckan, Ragnar K. [1 ,3 ]
Paulssen, Eyvind J. [2 ,3 ]
Asfeldt, Anne Mette [4 ]
Mortensen, Liisa [5 ]
Straume, Bjorn [4 ]
Florholmen, Jon [2 ,3 ]
机构
[1] Nordland Hosp, Dept Internal Med, NO-8092 Bodo, Norway
[2] Univ Hosp N Norway, Dept Gastroenterol, Tromso, Norway
[3] Univ Tromso, Inst Clin Med, Tromso, Norway
[4] Univ Tromso, Inst Community Med, Tromso, Norway
[5] Nordland Hosp, Dept Microbiol, NO-8092 Bodo, Norway
关键词
Body mass index; gastro-oesophageal reflux; heartburn; Helicobacter pylori; population; GASTROINTESTINAL SYMPTOMS; RISK-FACTORS; SWEDISH POPULATION; RATING-SCALE; DISEASE; PREVALENCE; DYSPEPSIA; ESOPHAGITIS; DEFINITION; OBESITY;
D O I
10.1080/00365520903093728
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Objective. Increased body mass index (BMI) has been proposed as a risk factor for gastro-oesophageal reflux symptoms. The aim of this study was to evaluate the effect of BMI and Helicobacter pylori on reflux symptoms in an adult population. Material and methods. For this cross-sectional, population-based study from Bodo and Sorreisa communities in Northern Norway, a total of 3927 adults were invited to complete a questionnaire on gastrointestinal symptoms and to provide stool samples for the assessment of H. pylori. Reflux symptoms were considered present when a reflux syndrome score was] 2 according to the Gastrointestinal Symptom Rating Scale (GSRS). Results. The response rate was 44.2%, and 44.7% of the respondents were male. Age-adjusted prevalences were: for overweight, 35.6% (95% CI (32.4%; 38.8%)); for obesity, 10.0% (8.4%; 11.6%); for H. pylori: 21.2% (19.1%; 23.9%) and for reflux symptoms: 21.7% (19.5%; 23.9%). In the logistic regression analyses, H. pylori and smoking were not risk factors for reflux symptoms, whereas male gender (OR 4.78 (95% CI (1.88; 12.1)), age (1.01 (1.00; 1.03)) and overweight (1.51 (1.14; 2.00)) were. When stratified by gender, overweight and age were independent risk factors for reflux symptoms in females only, whereas H. pylori infection was protective against such symptoms in men. Models including these parameters could only explain 3% of the variations in reflux symptoms. Conclusions. BMI is an independent risk factor for gastro-oesophageal reflux symptoms among healthy female adults, but contributes only to a minor part of the variation in these symptoms. H. pylori is protective against reflux symptoms in men.
引用
收藏
页码:1060 / 1066
页数:7
相关论文
共 40 条
  • [1] The cost of gastro-oesophageal reflux disease, dyspepsia and peptic ulcer disease in Sweden
    Agréus, L
    Borgquist, L
    [J]. PHARMACOECONOMICS, 2002, 20 (05) : 347 - 355
  • [2] Altman DG, 2000, Statistics with confidence, V2nd
  • [3] [Anonymous], 1995, B WORLD HEALTH ORGAN, P854
  • [4] Accuracy of a monoclonal antibody-based stool antigen test in the diagnosis of Helicobacter pylori infection
    Asfeldt, AM
    Lochen, ML
    Straume, B
    Steigen, SE
    Florholmen, J
    Goll, R
    Nestegard, O
    Paulssen, EJ
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2004, 39 (11) : 1073 - 1077
  • [5] Changes in the prevalence of dyspepsia and Helicobacter pylori infection after 17 years:: The Sorreisa gastrointestinal disorder study
    Asfeldt, Anne Mette
    Straume, Bjorn
    Steigen, Sonja Eriksson
    Lochen, Maja-Lisa
    Florholmen, Jon
    Bernersen, Bjorn
    Johnsen, Roar
    Paulssen, Eyvind J.
    [J]. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 2008, 23 (09) : 625 - 633
  • [6] Risk factors for dyspepsia in a general population:: Non-steroidal anti-inflammatory drugs, cigarette smoking and unemployment are more important than Helicobacter pylori infection
    Christensen, MW
    Hansen, JM
    De Muckadell, OBS
    [J]. SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY, 2006, 41 (02) : 149 - 154
  • [7] Abdominal obesity, ethnicity and gastro-oesophageal reflux symptoms
    Corley, Douglas A.
    Kubo, Ai
    Zhao, Wei
    [J]. GUT, 2007, 56 (06) : 756 - 762
  • [8] Body mass index and gastroesophageal reflux disease: A systematic review and meta-analysis
    Corley, Douglas A.
    Kubo, Ai
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2006, 101 (11) : 2619 - 2628
  • [9] Gastroesophageal pressure gradients in gastroesophageal reflux disease: Relations with hiatal hernia, body mass index, and esophageal acid exposure
    de Vries, Durk R.
    Van Herwaarden, Margot A.
    Smout, Andre J. P. M.
    Samsom, Melvin
    [J]. AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (06) : 1349 - 1354
  • [10] Epidemiology of gastrooesophageal reflux disease: A systematic review
    Dent, J
    El-Serag, HB
    Wallander, MA
    Johansson, S
    [J]. GUT, 2005, 54 (05) : 710 - 717