A synthesis of cytonin (taiwanin A), an antitumor lignan

被引：0
|
作者：
Jiaang, WT [1 ]
Wang, CL
Tseng, A
Chen, ST
机构：
[1] Acad Sinica, Inst Biol Chem, Taipei 115, Taiwan
[2] Alps Biotech Co Ltd, Taipei 105, Taiwan
[3] Analyt Ltd, Melbourne, Vic, Australia
来源：
HETEROCYCLES | 2000年 / 53卷 / 07期
关键词：
Stobble condensation; DIBALH; piperonal;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new procedure for the synthesis of the antitumor substance: cytonin (taiwanin A) is described. Stobbe reaction, using diethyl succinate with piperonal in a 2:1 molar ratio, produced 2E,3E-dipiperonylidenesuccinic acid. Dehydration to the anhydride, followed by reduction with DIBALH gave hydroxy acid. Subsequent cyclization of the hydroxy acid resulted in 21% total yield of cytonin.
引用
收藏
页码：1569 / 1572
页数：4
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