'On water synthesis' of oxindoles bearing quaternary carbon center through C-H (sp3) functionalization of methyl azaarenes

被引：29
|
作者：
Yaragorla, Srinivasarao [1 ]
Singh, Garima [1 ]
Dada, Ravikrishna [1 ]
机构：
[1] Cent Univ Rajasthan, Dept Chem, NH 8, Bandarsindri 305817, Rajasthan, India
来源：
TETRAHEDRON LETTERS | 2016年 / 57卷 / 05期
关键词：
3,3-Disubstituted oxindoles; sp(3) C-H functionalization; On-water synthesis; Multicomponent reactions; Heterocyclic compounds; SUBSTITUTED; 3-HYDROXY-2-OXINDOLES; C(SP(3))-H FUNCTIONALIZATION; FACILE SYNTHESIS; CONSTRUCTION; DERIVATIVES; INHIBITORS; BOND;
D O I：
10.1016/j.tetlet.2015.12.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A catalyst-free and green approach of sp(3) C-H functionalization of methyl azaarenes with malononitrile and isatins for the synthesis of oxindole derivatives bearing quaternary carbon center has been described in water. This one-pot three component synthesis endures the key features like first 'on water synthesis', short reaction times, moderate to good yields, and large substrate scope. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：591 / 594
页数：4
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