Preparation of Novel pH-Sensitive Nanocomposites Based on Ionic-Liquid Modified Montmorillonite for Colon Specific Drug Delivery System

被引：33

作者：

Mahkam, Mehrdad ^{[1
]}

Rafi, Abdolrahim Abbaszad ^{[1
]}

Gheshlaghi, Leila Mohammadzadeh ^{[1
]}

机构：

[1] Azarbaijan Shahid Madani Univ, Dept Chem, Tabriz, Iran

来源：

POLYMER COMPOSITES | 2016年 / 37卷 / 01期

关键词：

RELEASE; COMPOSITE; HYDROGEL; BEHAVIOR;

D O I：

10.1002/pc.23169

中图分类号：

TB33 [复合材料];

学科分类号：

摘要：

An ionic liquid monomer, 3-methyl-1-[2-(2-methyl-acryloxy)-ethyl]-imidazolium chloride, was synthesized through the quaternization of N-methylimidazole and 2-chloroethyl methacrylate. This ionic liquid monomer intercalated into the montmorillonite layers and subsequently copolymerized with methacrylic acid. The organic-inorganic composite was characterized by FTIR, XRD, SEM, and EDX to study their structure and properties. Naproxen as a model drug was entrapped in these pH-sensitive positively charged nano carriers and the in vitro release profiles were established separately in both enzyme-free simulated gastric and intestinal fluids (SGF, pH 1) and (SIF, pH 7.4) respectively. It was observed that the drug release percentages in SIF were higher; hence the prepared nanocomposite could be considered as a suitable carrier for colon specific drug delivery. (C) 2014 Society of Plastics Engineers

引用

页码：182 / 187

页数：6

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