Translational and basic science opportunities in palliative care and radiation oncology

被引：1

作者：

Mai Anh Huynh ^{[1
]}

Spektor, Alexander ^{[1
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA

来源：

ANNALS OF PALLIATIVE MEDICINE | 2019年 / 8卷 / 03期

关键词：

Palliative; radiation; oligometastases; translational; microenvironment; CELL LUNG-CANCER; VERTEBRAL COMPRESSION FRACTURE; BRAIN METASTASES JLGK0901; STEREOTACTIC RADIOSURGERY; SPINAL INSTABILITY; IONIZING-RADIATION; PREDICTIVE MODEL; BONE METASTASES; BREAST-CANCER; THERAPY;

D O I：

10.21037/apm.2019.07.08

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Radiation therapy is commonly used in the metastatic setting to palliate pain, neurological deficits, bleeding and other complications of metastatic disease, allowing patients to live longer and have better quality of life. Despite the effective use of radiation and other palliative treatment modalities, many patients continue to experience poorly controlled pain and other serious sequelae of their disease, underscoring the need for additional research in this area. In this review we highlight recent developments impacting the fields of palliative care and radiation oncology and describe opportunities for research and innovation including studies of tumor microenvironment, identification of effective biomarkers of tumor response and combinatorial treatments with new systemic agents. It is our hope that progress in these fields will improve the lives of patients living with advanced malignancies.

引用

页码：326 / 336

页数：11

共 78 条

[21] Local Consolidative Therapy Vs. Maintenance Therapy or Observation for Patients With Oligometastatic Non-Small-Cell Lung Cancer: Long-Term Results of a Multi-Institutional, Phase II, Randomized Study [J].

Gomez, Daniel R. ;

Tang, Chad ;

Zhang, Jianjun ;

Blumenschein, George R., Jr. ;

Hernandez, Mike ;

Lee, J. Jack ;

Ye, Rong ;

Palma, David A. ;

Louie, Alexander, V ;

Camidge, D. Ross ;

Doebele, Robert C. ;

Skoulidis, Ferdinandos ;

Gaspar, Laurie E. ;

Welsh, James W. ;

Gibbons, Don L. ;

Karam, Jose A. ;

Kavanagh, Brian D. ;

Tsao, Anne S. ;

Sepesi, Boris ;

Swisher, Stephen G. ;

Heymach, John, V .

JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (18) :1558-1565

[22] Local consolidative therapy versus maintenance therapy or observation for patients with oligometastatic non-small-cell lung cancer without progression after first-line systemic therapy: a multicentre, randomised, controlled, phase 2 study [J].

Gomez, Daniel R. ;

Blumenschein, George R., Jr. ;

Lee, J. Jack ;

Hernandez, Mike ;

Ye, Rong ;

Camidge, D. Ross ;

Doebele, Robert C. ;

Skoulidis, Ferdinandos ;

Gaspar, Laurie E. ;

Gibbons, Don L. ;

Karam, Jose A. ;

Kavanagh, Brian D. ;

Tang, Chad ;

Komaki, Ritsuko ;

Louie, Alexander V. ;

Palma, David A. ;

Tsao, Anne S. ;

Sepesi, Boris ;

William, William N. ;

Zhang, Jianjun ;

Shi, Qiuling ;

Wang, Xin Shelley ;

Swisher, Stephen G. ;

Heymach, John V. .

LANCET ONCOLOGY, 2016, 17 (12) :1672-1682

[23] Survival prediction in terminally ill cancer patients by clinical estimates, laboratory tests, and self-rated anxiety and depression [J].

Gripp, Stephan ;

Moeller, Sibylle ;

Boelke, Edwin ;

Schmitt, Gerd ;

Matuschek, Christiane ;

Asgari, Sonja ;

Asgharzadeh, Farzin ;

Roth, Stephan ;

Budach, Wilfried ;

Franz, Matthias ;

Willers, Reinhardt .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (22) :3313-3320

[24] Use of Radiation Therapy in the Last 30 Days of Life Among a Large Population-Based Cohort of Elderly Patients in the United States [J].

Guadagnolo, B. Ashleigh ;

Liao, Kai-Ping ;

Elting, Linda ;

Giordano, Sharon ;

Buchholz, Thomas A. ;

Shih, Ya-Chen Tina .

JOURNAL OF CLINICAL ONCOLOGY, 2013, 31 (01) :80-87

[25]

Guise T. A., 2002, Journal of Musculoskeletal & Neuronal Interactions, V2, P570

[26] Breast carcinoma - Associated fibroblasts and their counterparts display neoplastic-specific changes [J].

Hawsawi, Nahed M. ;

Ghebeh, Hazent ;

Hendrayani, Siti-Faujiah ;

Tulbah, Asma ;

Al-Eid, Maha ;

Al-Tweigeri, Taher ;

Ajarim, Dahish ;

Alaiya, Ayodele ;

Dermime, Said ;

Aboussekhra, Abdelilah .

CANCER RESEARCH, 2008, 68 (08) :2717-2725

[27] Cancer-associated fibroblasts from human NSCLC survive ablative doses of radiation but their invasive capacity is reduced [J].

Hellevik, Turid ;

Pettersen, Ingvild ;

Berg, Vivian ;

Winberg, Jan Olof ;

Moe, Bjorn T. ;

Bartnes, Kristian ;

Paulssen, Ruth H. ;

Busund, Lill-Tove ;

Bremnes, Roy ;

Chalmers, Anthony ;

Martinez-Zubiaurre, Inigo .

RADIATION ONCOLOGY, 2012, 7

[28] OLIGOMETASTASES [J].

HELLMAN, S ;

WEICHSELBAUM, RR .

JOURNAL OF CLINICAL ONCOLOGY, 1995, 13 (01) :8-10

[29] Safety of combining radiotherapy with immune-checkpoint inhibition [J].

Hwang, William L. ;

Pike, Luke R. G. ;

Royce, Trevor J. ;

Mahal, Brandon A. ;

Loeffler, Jay S. .

NATURE REVIEWS CLINICAL ONCOLOGY, 2018, 15 (08) :477-494

[30] Consolidative Radiotherapy for Limited Metastatic Non-Small-Cell Lung Cancer A Phase 2 Randomized Clinical Trial [J].

Iyengar, Puneeth ;

Wardak, Zabi ;

Gerber, David E. ;

Tumati, Vasu ;

Ahn, Chul ;

Hughes, Randall S. ;

Dowell, Jonathan E. ;

Cheedella, Naga ;

Nedzi, Lucien ;

Westover, Kenneth D. ;

Pulipparacharuvil, Suprabha ;

Choy, Hak ;

Timmerman, Robert D. .

JAMA ONCOLOGY, 2018, 4 (01)

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