"Cloud-like Enhancement" Is a Magnetic Resonance Imaging Abnormality Specific to Neuromyelitis Optica

被引：127

作者：

Ito, Shoichi ^{[1
]}

Mori, Masahiro ^{[1
]}

Makino, Takahiro ^{[1
]}

Hayakawa, Sei ^{[1
]}

Kuwabara, Satoshi ^{[1
]}

机构：

[1] Chiba Univ, Dept Neurol, Grad Sch Med, Chiba, Japan

来源：

ANNALS OF NEUROLOGY | 2009年 / 66卷 / 03期

关键词：

MULTIPLE-SCLEROSIS; DIAGNOSTIC-CRITERIA; LESIONS; AQUAPORIN-4; PATHOGENESIS; NMO;

D O I：

10.1002/ana.21753

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Neuromyelitis optica (NMO) is presumably mediated by all autoantibody against aquaporin-4 densely expressed at the blood-brain barrier. In 18 patients with NMO, brain magnetic resonance imaging (MRI) findings were systematically, reviewed. Brain MRI abnormalities were found for 89% of the patients, and the most prominent feature was "cloud-like enhancement," multiple patchy enhancing lesions with blurred margin, found in 90% of the patients with positive contrast enhancement. In NMO, brain MRI abnormalities are frequent, and cloud-like enhancement appears to be an MRI finding specific to NMO, possibly caused by primary involvement of the blood-brain barrier by the autoantibodies.

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收藏

页码：425 / 428

页数：4

相关论文

共 20 条

[1] Brain magnetic resonance imaging findings in relapsing neuromyelitis optica [J].

Cabrera-Gomez, Jose A. ;

Quevedo-Sotolongo, L. ;

Gonzalez-Quevedo, A. ;

Lima, S. ;

Real-Gonzalez, Y. ;

Cristofol-Corominas, M. ;

Romero-Garcia, K. ;

Ugarte-Sanchez, C. ;

Jordan-Gonzalez, J. ;

Gonzalez de la Nuez, J. E. ;

Garcia Lahera, J. ;

Tellez, R. ;

Pedroso-Ibanez, I. ;

Rodriguez Roca, R. ;

Cabrera-Nunez, A. Y. .

MULTIPLE SCLEROSIS, 2007, 13 (02) :186-192

[2] Neuromyelitis optica and anti-aquaporin-4 antibodies measured by an enzyme-linked immunosorbent assay [J].

Hayakawa, Sei ;

Mori, Masahiro ;

Okuta, Akiko ;

Kamegawa, Akiko ;

Fujiyoshi, Yoshinori ;

Yoshiyama, Yasumasa ;

Mitsuoka, Kaoru ;

Ishibashi, Kenichi ;

Sasaki, Sei ;

Hattori, Takamichi ;

Kuwabara, Satoshi .

JOURNAL OF NEUROIMMUNOLOGY, 2008, 196 (1-2) :181-187

[3] Impaired hypothalamus-pituitary-adrenal axis activity and more severe multiple sclerosis with hypothalamic lesions [J].

Huitinga, I ;

Erkut, ZA ;

van Beurden, D ;

Swaab, DF .

ANNALS OF NEUROLOGY, 2004, 55 (01) :37-45

[4] IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel [J].

Lennon, VA ;

Kryzer, TJ ;

Pittock, SJ ;

Verkman, AS ;

Hinson, SR .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (04) :473-477

[5] Brain magnetic resonance imaging abnormalities in neuromyelitis optica [J].

Li, Y. ;

Xie, P. ;

Lv, F. ;

Mu, J. ;

Li, Q. ;

Yang, Q. ;

Hu, M. ;

Tang, H. ;

Yi, J. .

ACTA NEUROLOGICA SCANDINAVICA, 2008, 118 (04) :218-225

[6] Heterogeneity of aquaporin-4 autoimmunity and spinal cord lesions in multiple sclerosis in Japanese [J].

Matsuoka, Takeshi ;

Matsushita, Takuya ;

Kawano, Yuji ;

Osoegawa, Manabu ;

Ochi, Hirofumi ;

Ishizu, Takaaki ;

Minohara, Motozumi ;

Kikuchi, Hitoshi ;

Mihara, Futoshi ;

Ohyagi, Yasumasa ;

Kira, Jun-ichi .

BRAIN, 2007, 130 :1206-1223

[7] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].

McDonald, WI ;

Compston, A ;

Edan, G ;

Goodkin, D ;

Hartung, HP ;

Lublin, FD ;

McFarland, HF ;

Paty, DW ;

Polman, CH ;

Reingold, SC ;

Sandberg-Wollheim, M ;

Sibley, W ;

Thompson, AJ ;

van den Noort, S ;

Weinshenker, BY ;

Wolinsky, JS .

ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127

[8] Loss of aquaporin 4 in lesions of neuromyelitis optica: distinction from multiple sclerosis [J].

Misu, T. ;

Fujihara, K. ;

Kakita, A. ;

Konno, H. ;

Nakamura, M. ;

Watanabe, S. ;

Takahashi, T. ;

Nakashima, I. ;

Takahashi, H. ;

Itoyama, Y. .

BRAIN, 2007, 130 :1224-1234

[9] Cortical demyelination in PML and MS - Similarities and differences [J].

Moll, N. M. ;

Rietsch, A. M. ;

Ransohoff, A. J. ;

Cossoy, M. B. ;

Huang, D. ;

Eichler, F. S. ;

Trapp, B. D. ;

Ransohoff, R. M. .

NEUROLOGY, 2008, 70 (05) :336-343

[10] Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression [J].

Pittock, Sean J. ;

Weinshenker, Brian G. ;

Lucchinetti, Claudia F. ;

Wingerchuk, Dean M. ;

Corboy, John R. ;

Lennon, Vanda A. .

ARCHIVES OF NEUROLOGY, 2006, 63 (07) :964-968