Ubiquitin-like proteins: new wines in new bottles

被引：418

作者：

Yeh, ETH ^{[1
]}

Gong, LM

Kamitani, T

机构：

[1] Univ Texas, Hlth Sci Ctr, Div Cardiol, Sch Med, Houston, TX 77030 USA

[2] Univ Texas, Hlth Sci Ctr, Div Mol Med, Sch Med, Houston, TX 77030 USA

[3] Univ Texas, Hlth Sci Ctr, Res Ctr Cardiovasc Dis, Inst Mol Med Prevent Human Dis, Houston, TX 77030 USA

来源：

GENE | 2000年 / 248卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

cullin; NEDD8; protein modification; sentrin; SUMO; ubiquitin;

D O I：

10.1016/S0378-1119(00)00139-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 14

页数：14

共 124 条

[31]

Haas AL, 1997, FASEB J, V11, P1257

[32] Modulation of ETS-1 transcriptional activity by huUBC9, a ubiquitin-conjugating enzyme [J].

Hahn, SL ;

Criqui, P ;

Wasylyk, B .

ONCOGENE, 1997, 15 (12) :1489-1495

[33] mUBC9, a novel adenovirus E1A-interacting protein that complements a yeast cell cycle defect [J].

Hateboer, G ;

Hijmans, EM ;

Nooij, JBD ;

Schlenker, S ;

Jentsch, S ;

Bernards, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (42) :25906-25911

[34] The ubiquitin system [J].

Hershko, A ;

Ciechanover, A .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :425-479

[35] Ubiquitin-dependent internalization and down-regulation of plasma membrane proteins [J].

Hicke, L .

FASEB JOURNAL, 1997, 11 (14) :1215-1226

[36] Covalent modification of all members of human cullin family proteins by NEDD8 [J].

Hori, T ;

Osaka, F ;

Chiba, T ;

Miyamoto, C ;

Okabayashi, K ;

Shimbara, N ;

Kato, S ;

Tanaka, K .

ONCOGENE, 1999, 18 (48) :6829-6834

[37]

Hu G, 1999, MOL CELL BIOL, V19, P724

[38] Characterization of the mUBC9-binding sites required for E2A protein degradation [J].

Huggins, GS ;

Chin, MT ;

Sibinga, NES ;

Lee, SL ;

Haber, E ;

Lee, ME .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (40) :28690-28696

[39] PML is critical for ND10 formation and recruits the PML-interacting protein Daxx to this nuclear structure when modified by SUMO-1 [J].

Ishov, AM ;

Sotnikov, AG ;

Negorev, D ;

Vladimirova, OV ;

Neff, N ;

Kamitani, T ;

Yeh, ETH ;

Strauss, JF ;

Maul, GG .

JOURNAL OF CELL BIOLOGY, 1999, 147 (02) :221-233

[40]

Jiang WD, 1996, MOL GEN GENET, V251, P153

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