Ubiquitin-like proteins: new wines in new bottles

被引：418

作者：

Yeh, ETH ^{[1
]}

Gong, LM

Kamitani, T

机构：

[1] Univ Texas, Hlth Sci Ctr, Div Cardiol, Sch Med, Houston, TX 77030 USA

[2] Univ Texas, Hlth Sci Ctr, Div Mol Med, Sch Med, Houston, TX 77030 USA

[3] Univ Texas, Hlth Sci Ctr, Res Ctr Cardiovasc Dis, Inst Mol Med Prevent Human Dis, Houston, TX 77030 USA

来源：

GENE | 2000年 / 248卷 / 1-2期

基金：

美国国家卫生研究院;

关键词：

cullin; NEDD8; protein modification; sentrin; SUMO; ubiquitin;

D O I：

10.1016/S0378-1119(00)00139-6

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. (C) 2000 Elsevier Science B.V. All rights reserved.

引用

页码：1 / 14

页数：14

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