Ubiquitin-like proteins: new wines in new bottles

被引：417
作者：
Yeh, ETH [1 ]
Gong, LM
Kamitani, T
机构：
[1] Univ Texas, Hlth Sci Ctr, Div Cardiol, Sch Med, Houston, TX 77030 USA
[2] Univ Texas, Hlth Sci Ctr, Div Mol Med, Sch Med, Houston, TX 77030 USA
[3] Univ Texas, Hlth Sci Ctr, Res Ctr Cardiovasc Dis, Inst Mol Med Prevent Human Dis, Houston, TX 77030 USA
来源：
GENE | 2000年 / 248卷 / 1-2期
基金：
美国国家卫生研究院;
关键词：
cullin; NEDD8; protein modification; sentrin; SUMO; ubiquitin;
D O I：
10.1016/S0378-1119(00)00139-6
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
Ubiquitin is a small polypeptide that covalently modifies other cellular proteins and targets them to the proteasome for degradation. In recent years, ubiquitin-dependent proteolysis has been demonstrated to play a critical role in the regulation of many cellular processes, such as cell cycle progression, cell signaling, and immune recognition. The recent discovery of three new ubiquitin-like proteins, NEDD8, Sentrin/SUMO, and Apg12, has further broadened the horizon of this type of post-translational protein modification. This review will focus on the biology and biochemistry of the Sentrin/SUMO and NEDD8 modification pathways, which are clearly distinct from the ubiquitination pathway and have unique biological functions. (C) 2000 Elsevier Science B.V. All rights reserved.
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页码：1 / 14
页数：14
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