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Nankai Univ, Key Lab Mol Microbiol & Technol, State Key Lab Med Chem Biol, Minist Educ,Dept Microbiol,Coll Life Sci, Tianjin, Peoples R China Nankai Univ, Key Lab Mol Microbiol & Technol, State Key Lab Med Chem Biol, Minist Educ,Dept Microbiol,Coll Life Sci, Tianjin, Peoples R China