Localization of a blood pressure QTL on rat chromosome 1 using Dahl rat congenic strains

被引：24

作者：

Saad, Y ^{[1
]}

Garrett, MR ^{[1
]}

Lee, SJ ^{[1
]}

Dene, H ^{[1
]}

Rapp, JP ^{[1
]}

机构：

[1] Med Coll Ohio, Dept Physiol & Mol Med, Toledo, OH 43614 USA

来源：

PHYSIOLOGICAL GENOMICS | 1999年 / 1卷 / 03期

关键词：

Sa gene; genetic hypertension; salt-sensitive hypertension; cardiac hypertrophy;

D O I：

10.1152/physiolgenomics.1999.1.3.119

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We previously reported that markers on rat chromosome 1 are genetically linked to blood pressure in an F-2 population derived from Dahl salt hypertension-sensitive (S) and Lewis (LEW) rats. Because there was evidence for more than one blood pressure quantitative trait locus (QTL) on chromosome 1, an initial congenic strain introgressing a large 118-centimorgan (cM) segment of LEW chromosome 1 into the S background had been constructed. This initial congenic strain had a reduced blood pressure compared with S rats, proving the existence of a blood pressure QTL, but not giving a good localization of the QTL. In the present work a series of five overlapping congenic substrains were produced from the original congenic strain in order to localize a blood pressure QTL to a 25-cM region near the center of chromosome 1. The congenic substrains also ruled out the Sa locus as a blood pressure QTL in the S vs. LEW comparison because the Sa locus was contained in a congenic substrain that did not alter blood pressure.

引用

页码：119 / 125

页数：7