Large genomic differences between Moraxella bovoculi isolates acquired from the eyes of cattle with infectious bovine keratoconjunctivitis versus the deep nasopharynx of asymptomatic cattle

被引：34

作者：

Dickey, Aaron M. ^{[1
]}

Loy, John D. ^{[2
]}

Bono, James L. ^{[1
]}

Smith, Timothy P. L. ^{[1
]}

Apley, Mike D. ^{[3
]}

Lubbers, Brian V. ^{[4
]}

DeDonder, Keith D. ^{[3
]}

Capik, Sarah F. ^{[3
]}

Larson, Robert L. ^{[3
]}

White, Brad J. ^{[3
]}

Blom, Jochen ^{[5
]}

Chitko-McKown, Carol G. ^{[1
]}

Clawson, Michael L. ^{[1
]}

机构：

[1] ARS, USDA, USMARC, State Spur 18D, Clay Ctr, NE 68933 USA

[2] Univ Nebraska, Sch Vet Med & Biomed Sci, Lincoln, NE 68583 USA

[3] Kansas State Univ, Coll Vet Med, Manhattan, KS 66506 USA

[4] Kansas State Univ, Kansas State Diagnost Lab, Manhattan, KS 66506 USA

[5] Univ Giessen, Bioinformat & Syst Biol, D-35392 Giessen, Germany

来源：

VETERINARY RESEARCH | 2016年 / 47卷

基金：

美国食品与农业研究所;

关键词：

SP-NOV; STRAINS; VACCINE; IDENTIFICATION; NETWORKS; SOFTWARE; SPP;

D O I：

10.1186/s13567-016-0316-2

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

Moraxella bovoculi is a recently described bacterium that is associated with infectious bovine keratoconjunctivitis (IBK) or "pinkeye" in cattle. In this study, closed circularized genomes were generated for seven M. bovoculi isolates: three that originated from the eyes of clinical IBK bovine cases and four from the deep nasopharynx of asymptomatic cattle. Isolates that originated from the eyes of IBK cases profoundly differed from those that originated from the nasopharynx of asymptomatic cattle in genome structure, gene content and polymorphism diversity and consequently placed into two distinct phylogenetic groups. These results suggest that there are genetically distinct strains of M. bovoculi that may not associate with IBK.

引用

页数：11

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