Immunopathogenesis of inflammatory bowel disease

被引:162
作者
Matricon, Julien [1 ]
机构
[1] Univ Auvergne, Clermont Univ, Pharmacol Fondamentale & Clin Douleur, Lab Pharmacol Med,INSERM,U766, F-63000 Clermont Ferrand, France
来源
M S-MEDECINE SCIENCES | 2010年 / 26卷 / 04期
关键词
CROHNS-DISEASE; EXPRESSION; CELLS; NOD2; INTERLEUKIN-17; ANTIBODIES; IMMUNITY; GENES; COLON;
D O I
10.1051/medsci/2010264405
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Inflammatory bowel diseases (IBD) are idiopathic, chronic and relapsing inflammatory conditions of the gastrointestinal tract. New insights into the pathogenesis of IBD have been provided by three lines of research: (1) studying susceptibility genes involved in the detection of bacterial components and in the regulation of the host immune response, (2) highlighting the disruption of tolerance towards the commensal microbiota and (3) unravelling the critical role of environmental factors such as sanitation and hygiene. This review presents current etiological hypothesis of IBD which argue that pathogenic intestinal bacteria and/or infectious agents initiate and perpetuate the inflammation of the gut in an individual with genetic vulnerability leading to impaired epithelial barrier function and abnormal mucosal immune responses.
引用
收藏
页码:405 / 410
页数:6
相关论文
共 29 条
[1]   IgG antibodies against common gut bacteria are more diagnostic for Crohn's disease than IgG against mannan or flagellin [J].
Adams, Rachel J. ;
Heazlewood, Sharise P. ;
Gilshenan, Kristen S. ;
O'Brien, Mark ;
McGuckin, Michael A. ;
Florin, Timothy H. J. .
AMERICAN JOURNAL OF GASTROENTEROLOGY, 2008, 103 (02) :386-396
[2]  
Bamias Giorgos, 2003, Curr Opin Investig Drugs, V4, P1279
[3]   Gastroenterology 1 - Inflammatory bowel disease: cause and immunobiology [J].
Baumgart, Daniel C. ;
Carding, Simon R. .
LANCET, 2007, 369 (9573) :1627-1640
[4]   Gastroenterology 2 - Inflammatory bowel disease: clinical aspects and established and evolving therapies [J].
Baumgart, Daniel C. ;
Sandborn, William J. .
LANCET, 2007, 369 (9573) :1641-1657
[5]   Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells [J].
Bettelli, E ;
Carrier, YJ ;
Gao, WD ;
Korn, T ;
Strom, TB ;
Oukka, M ;
Weiner, HL ;
Kuchroo, VK .
NATURE, 2006, 441 (7090) :235-238
[6]   Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls [J].
Burton, Paul R. ;
Clayton, David G. ;
Cardon, Lon R. ;
Craddock, Nick ;
Deloukas, Panos ;
Duncanson, Audrey ;
Kwiatkowski, Dominic P. ;
McCarthy, Mark I. ;
Ouwehand, Willem H. ;
Samani, Nilesh J. ;
Todd, John A. ;
Donnelly, Peter ;
Barrett, Jeffrey C. ;
Davison, Dan ;
Easton, Doug ;
Evans, David ;
Leung, Hin-Tak ;
Marchini, Jonathan L. ;
Morris, Andrew P. ;
Spencer, Chris C. A. ;
Tobin, Martin D. ;
Attwood, Antony P. ;
Boorman, James P. ;
Cant, Barbara ;
Everson, Ursula ;
Hussey, Judith M. ;
Jolley, Jennifer D. ;
Knight, Alexandra S. ;
Koch, Kerstin ;
Meech, Elizabeth ;
Nutland, Sarah ;
Prowse, Christopher V. ;
Stevens, Helen E. ;
Taylor, Niall C. ;
Walters, Graham R. ;
Walker, Neil M. ;
Watkins, Nicholas A. ;
Winzer, Thilo ;
Jones, Richard W. ;
McArdle, Wendy L. ;
Ring, Susan M. ;
Strachan, David P. ;
Pembrey, Marcus ;
Breen, Gerome ;
St Clair, David ;
Caesar, Sian ;
Gordon-Smith, Katherine ;
Jones, Lisa ;
Fraser, Christine ;
Green, Elain K. .
NATURE, 2007, 447 (7145) :661-678
[7]   Differential alteration in intestinal epithelial cell expression of Toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease [J].
Cario, E ;
Podolsky, DK .
INFECTION AND IMMUNITY, 2000, 68 (12) :7010-7017
[8]   The genetics and immunopathogenesis of inflammatory bowel disease [J].
Cho, Judy H. .
NATURE REVIEWS IMMUNOLOGY, 2008, 8 (06) :458-466
[9]   Increased expression of interleukin 17 in inflammatory bowel disease [J].
Fujino, S ;
Andoh, A ;
Bamba, S ;
Ogawa, A ;
Hata, K ;
Araki, Y ;
Bamba, T ;
Fujiyama, Y .
GUT, 2003, 52 (01) :65-70
[10]   Characteristics of intestinal dendritic cells in inflammatory bowel diseases [J].
Hart, AL ;
Al-Hassi, HO ;
Rigby, RJ ;
Bell, SJ ;
Emmanuel, AV ;
Knight, SC ;
Kamm, MA ;
Stagg, AJ .
GASTROENTEROLOGY, 2005, 129 (01) :50-65