iso-α-Cyclopiazonic acid, a new natural product isolated from the marine-derived fungus Aspergillus flavus C-F-3

被引：44
|
作者：
Lin, Ai-Qun [1 ]
Du, Lin
Fang, Yu-Chun
Wang, Fa-Zuo
Zhu, Tian-Jiao
Gu, Qian-Qun
Zhu, Wei-Ming
机构：
[1] Ocean Univ China, Key Lab Marine Drugs, Chinese Minist Educ, Qingdao 266003, Peoples R China
来源：
CHEMISTRY OF NATURAL COMPOUNDS | 2009年 / 45卷 / 05期
关键词：
Aspergillus flavus; cyclopiazonic acid; cytotoxic activity; SARCOPLASMIC-RETICULUM; BIOSYNTHESIS; CELLS; ASSAY;
D O I：
10.1007/s10600-009-9433-8
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A new natural product, iso-alpha-cyclopiazonic acid (1), together with its isomer alpha-cyclopiazonic acid (2); three mycotoxins: aflatoxin B-1 (AFB(1)) (3), aflatoxin Q(1) (AFQ(1)) (4), and O-methylsterigmatocystin (OMST) (5); two diketopiperazine alkaloids: ditryptophenaline (6) and 3-[(1H-indol-3-yl)methyl]-6-benzylpiperazine-2,5-dione (7), were isolated from the marine-derived fungus Aspergillus flavus. Their structures were determined by analysis of spectroscopic data. The cytotoxicities of compounds 1 and 2 were studied using HL-60, MOLT-4, A-549, and BEL-7402 cell lines.
引用
收藏
页码：677 / 680
页数：4
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